Could Biomarkers of Bone, Cartilage or Synovium Turnover Be Used for Relapse Prediction in Rheumatoid Arthritis Patients?
Objective. The aim of this review is to clarify the usefulness of bone, cartilage, and synovial biomarker in the management of rheumatoid arthritis (RA) therapy in remission. Synovial Biomarkers. High MMP-3 levels are associated with joint progression in RA patients, but there is no data about their...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2014/537324 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832559113640345600 |
|---|---|
| author | Delphine Dénarié Elodie Constant Thierry Thomas Hubert Marotte |
| author_facet | Delphine Dénarié Elodie Constant Thierry Thomas Hubert Marotte |
| author_sort | Delphine Dénarié |
| collection | DOAJ |
| description | Objective. The aim of this review is to clarify the usefulness of bone, cartilage, and synovial biomarker in the management of rheumatoid arthritis (RA) therapy in remission. Synovial Biomarkers. High MMP-3 levels are associated with joint progression in RA patients, but there is no data about their utility in clinical remission. IIINys and Glc-Gal-PYD seem to be more specific to synovium, but more studies are required. Cartilage Biomarkers. Unbalance between cartilage break-down biomarkers (urinary CTX II and COMP) and cartilage formation biomarker (PIIANP) was described. This unbalance is also associated with joint destruction and prognosis of destruction. No data are available on patients in remission. Bone Biomarkers. RA activity is correlated with an increase of bone resorption markers such as CTX I, PYD, and TRACP 5b and a decrease of bone formation markers such as OC and BALP. RA therapies seem to improve bone turnover in limiting bone resorption. There is no study about bone marker utility in remission. Conclusion. Biomarkers seem to correlate with RA activity and progression. They also could be used to manage RA therapies, but we need more data on RA remission to predict relapse. |
| format | Article |
| id | doaj-art-f7dc057096f04ee9b8e69510d95a61c4 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-f7dc057096f04ee9b8e69510d95a61c42025-02-03T01:30:52ZengWileyMediators of Inflammation0962-93511466-18612014-01-01201410.1155/2014/537324537324Could Biomarkers of Bone, Cartilage or Synovium Turnover Be Used for Relapse Prediction in Rheumatoid Arthritis Patients?Delphine Dénarié0Elodie Constant1Thierry Thomas2Hubert Marotte3Department of Rheumatology, University Hospital Saint-Etienne, 42055 Saint-Etienne Cedex, FranceDepartment of Rheumatology, University Hospital Saint-Etienne, 42055 Saint-Etienne Cedex, FranceDepartment of Rheumatology, University Hospital Saint-Etienne, 42055 Saint-Etienne Cedex, FranceDepartment of Rheumatology, University Hospital Saint-Etienne, 42055 Saint-Etienne Cedex, FranceObjective. The aim of this review is to clarify the usefulness of bone, cartilage, and synovial biomarker in the management of rheumatoid arthritis (RA) therapy in remission. Synovial Biomarkers. High MMP-3 levels are associated with joint progression in RA patients, but there is no data about their utility in clinical remission. IIINys and Glc-Gal-PYD seem to be more specific to synovium, but more studies are required. Cartilage Biomarkers. Unbalance between cartilage break-down biomarkers (urinary CTX II and COMP) and cartilage formation biomarker (PIIANP) was described. This unbalance is also associated with joint destruction and prognosis of destruction. No data are available on patients in remission. Bone Biomarkers. RA activity is correlated with an increase of bone resorption markers such as CTX I, PYD, and TRACP 5b and a decrease of bone formation markers such as OC and BALP. RA therapies seem to improve bone turnover in limiting bone resorption. There is no study about bone marker utility in remission. Conclusion. Biomarkers seem to correlate with RA activity and progression. They also could be used to manage RA therapies, but we need more data on RA remission to predict relapse.http://dx.doi.org/10.1155/2014/537324 |
| spellingShingle | Delphine Dénarié Elodie Constant Thierry Thomas Hubert Marotte Could Biomarkers of Bone, Cartilage or Synovium Turnover Be Used for Relapse Prediction in Rheumatoid Arthritis Patients? Mediators of Inflammation |
| title | Could Biomarkers of Bone, Cartilage or Synovium Turnover Be Used for Relapse Prediction in Rheumatoid Arthritis Patients? |
| title_full | Could Biomarkers of Bone, Cartilage or Synovium Turnover Be Used for Relapse Prediction in Rheumatoid Arthritis Patients? |
| title_fullStr | Could Biomarkers of Bone, Cartilage or Synovium Turnover Be Used for Relapse Prediction in Rheumatoid Arthritis Patients? |
| title_full_unstemmed | Could Biomarkers of Bone, Cartilage or Synovium Turnover Be Used for Relapse Prediction in Rheumatoid Arthritis Patients? |
| title_short | Could Biomarkers of Bone, Cartilage or Synovium Turnover Be Used for Relapse Prediction in Rheumatoid Arthritis Patients? |
| title_sort | could biomarkers of bone cartilage or synovium turnover be used for relapse prediction in rheumatoid arthritis patients |
| url | http://dx.doi.org/10.1155/2014/537324 |
| work_keys_str_mv | AT delphinedenarie couldbiomarkersofbonecartilageorsynoviumturnoverbeusedforrelapsepredictioninrheumatoidarthritispatients AT elodieconstant couldbiomarkersofbonecartilageorsynoviumturnoverbeusedforrelapsepredictioninrheumatoidarthritispatients AT thierrythomas couldbiomarkersofbonecartilageorsynoviumturnoverbeusedforrelapsepredictioninrheumatoidarthritispatients AT hubertmarotte couldbiomarkersofbonecartilageorsynoviumturnoverbeusedforrelapsepredictioninrheumatoidarthritispatients |