High diversity of Escherichia coli causing invasive disease in neonates in Malawi poses challenges for O-antigen based vaccine approach

Abstract Background Escherichia coli is an important cause of neonatal sepsis and the third most prevalent cause of neonatal infection in sub-Saharan Africa, often with negative outcomes. Development of maternally administered vaccines is under consideration, but to provide adequate protection, an u...

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Bibliographic Details
Main Authors: Oliver Pearse, Allan Zuza, Edith Tewesa, Patricia Siyabu, Alice J. Fraser, Jennifer Cornick, Kondwani Kawaza, Patrick Musicha, Nicholas R. Thomson, Nicholas A. Feasey, Eva Heinz
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Communications Medicine
Online Access:https://doi.org/10.1038/s43856-025-01007-1
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