In vivo Mononuclear Phagocyte Migration: Paradoxical Effect of Adrenalectomy
The effect of adrenalectomy on neutrophil and monocyte migration into rat peritoneal and pleural cavities was investigated. Carrageenin- or thioglycollate-induced neutrophil emigration into both cavities was enhanced by adrenalectomy. In contrast, monocyte migration into peritoneal cavities induced...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
1994-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935194000372 |
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| _version_ | 1832564303222276096 |
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| author | N. E. Heluy-Neto F. Q. Cunha S. H. Ferreira |
| author_facet | N. E. Heluy-Neto F. Q. Cunha S. H. Ferreira |
| author_sort | N. E. Heluy-Neto |
| collection | DOAJ |
| description | The effect of adrenalectomy on neutrophil and monocyte migration
into rat peritoneal and pleural cavities was investigated.
Carrageenin- or thioglycollate-induced neutrophil emigration into
both cavities was enhanced by adrenalectomy. In contrast, monocyte
migration into peritoneal cavities induced by these two stimuli was
significantl decreased. In pleural cavities, adrenalectomy enhanced
the monocyte migration induced by carrageenin but had no effect on
that induced by thioglycollate. Administration of physiological
doses of glucocorticoids reversed the effect of adrenalectomy on
monocyte migration by both stimuli into both cavities. The results
support the hypothesis that endogenous glucocorticotds negatively
control neutrophil migration independently of the site or type of
stimulus. Their role in monocyte migration is, however, dependent on
the site of injury and on the type of inflammatory stimulus. There
is no obvious explanation for the divergent influence of endogenous
glucocorticoids on the monocyte emigration into peritoneal and
pleural cavities observed with different stimuli. |
| format | Article |
| id | doaj-art-f7b5c6c862ae467c99c10d96b2e11262 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1994-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-f7b5c6c862ae467c99c10d96b2e112622025-02-03T01:11:28ZengWileyMediators of Inflammation0962-93511466-18611994-01-013427527910.1155/S0962935194000372In vivo Mononuclear Phagocyte Migration: Paradoxical Effect of AdrenalectomyN. E. Heluy-Neto0F. Q. Cunha1S. H. Ferreira2Department of Pharmacology, Faculty of Medicine (Ribeirão Preto) USP, Av. Bandeirantes 3900, Ribeirão Preto, SP 14049-000, BrazilDepartment of Pharmacology, Faculty of Medicine (Ribeirão Preto) USP, Av. Bandeirantes 3900, Ribeirão Preto, SP 14049-000, BrazilDepartment of Pharmacology, Faculty of Medicine (Ribeirão Preto) USP, Av. Bandeirantes 3900, Ribeirão Preto, SP 14049-000, BrazilThe effect of adrenalectomy on neutrophil and monocyte migration into rat peritoneal and pleural cavities was investigated. Carrageenin- or thioglycollate-induced neutrophil emigration into both cavities was enhanced by adrenalectomy. In contrast, monocyte migration into peritoneal cavities induced by these two stimuli was significantl decreased. In pleural cavities, adrenalectomy enhanced the monocyte migration induced by carrageenin but had no effect on that induced by thioglycollate. Administration of physiological doses of glucocorticoids reversed the effect of adrenalectomy on monocyte migration by both stimuli into both cavities. The results support the hypothesis that endogenous glucocorticotds negatively control neutrophil migration independently of the site or type of stimulus. Their role in monocyte migration is, however, dependent on the site of injury and on the type of inflammatory stimulus. There is no obvious explanation for the divergent influence of endogenous glucocorticoids on the monocyte emigration into peritoneal and pleural cavities observed with different stimuli.http://dx.doi.org/10.1155/S0962935194000372 |
| spellingShingle | N. E. Heluy-Neto F. Q. Cunha S. H. Ferreira In vivo Mononuclear Phagocyte Migration: Paradoxical Effect of Adrenalectomy Mediators of Inflammation |
| title | In vivo Mononuclear Phagocyte Migration: Paradoxical Effect of Adrenalectomy |
| title_full | In vivo Mononuclear Phagocyte Migration: Paradoxical Effect of Adrenalectomy |
| title_fullStr | In vivo Mononuclear Phagocyte Migration: Paradoxical Effect of Adrenalectomy |
| title_full_unstemmed | In vivo Mononuclear Phagocyte Migration: Paradoxical Effect of Adrenalectomy |
| title_short | In vivo Mononuclear Phagocyte Migration: Paradoxical Effect of Adrenalectomy |
| title_sort | in vivo mononuclear phagocyte migration paradoxical effect of adrenalectomy |
| url | http://dx.doi.org/10.1155/S0962935194000372 |
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