In vivo Mononuclear Phagocyte Migration: Paradoxical Effect of Adrenalectomy
The effect of adrenalectomy on neutrophil and monocyte migration into rat peritoneal and pleural cavities was investigated. Carrageenin- or thioglycollate-induced neutrophil emigration into both cavities was enhanced by adrenalectomy. In contrast, monocyte migration into peritoneal cavities induced...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
1994-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935194000372 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | The effect of adrenalectomy on neutrophil and monocyte migration
into rat peritoneal and pleural cavities was investigated.
Carrageenin- or thioglycollate-induced neutrophil emigration into
both cavities was enhanced by adrenalectomy. In contrast, monocyte
migration into peritoneal cavities induced by these two stimuli was
significantl decreased. In pleural cavities, adrenalectomy enhanced
the monocyte migration induced by carrageenin but had no effect on
that induced by thioglycollate. Administration of physiological
doses of glucocorticoids reversed the effect of adrenalectomy on
monocyte migration by both stimuli into both cavities. The results
support the hypothesis that endogenous glucocorticotds negatively
control neutrophil migration independently of the site or type of
stimulus. Their role in monocyte migration is, however, dependent on
the site of injury and on the type of inflammatory stimulus. There
is no obvious explanation for the divergent influence of endogenous
glucocorticoids on the monocyte emigration into peritoneal and
pleural cavities observed with different stimuli. |
|---|---|
| ISSN: | 0962-9351 1466-1861 |