Ultrasound-assisted enhancement of bioactive compounds in hawthorn vinegar: A functional approach to anticancer and antidiabetic effects
In this study, the effects of ultrasound treatment on bioactive components and functional properties of hawthorn vinegar (Crataegus tanacetifolia) were investigated. Parameters such as total phenolic compound (TPC), total flavonoid content (TFC), ascorbic acid (AA), DPPH radical scavenging activity...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Ultrasonics Sonochemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1350417725000240 |
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| author | Selim Öğüt Melikenur Türkol Seydi Yıkmış Esra Bozgeyik Gholamreza Abdi Emine Kocyigit Rana Muhammad Aadil Nilay Seyidoglu Deniz Karakçı Nazlı Tokatlı |
| author_facet | Selim Öğüt Melikenur Türkol Seydi Yıkmış Esra Bozgeyik Gholamreza Abdi Emine Kocyigit Rana Muhammad Aadil Nilay Seyidoglu Deniz Karakçı Nazlı Tokatlı |
| author_sort | Selim Öğüt |
| collection | DOAJ |
| description | In this study, the effects of ultrasound treatment on bioactive components and functional properties of hawthorn vinegar (Crataegus tanacetifolia) were investigated. Parameters such as total phenolic compound (TPC), total flavonoid content (TFC), ascorbic acid (AA), DPPH radical scavenging activity and CUPRAC reducing capacity were optimised by surface response method (RSM) and 14 min duration and 61.40 % amplitude were determined as the most suitable treatment conditions. The results showed that ultrasound treatment improved the antioxidant properties of hawthorn vinegar by increasing TPC, TFC, DPPH and CUPRAC values. In addition, it was observed that hawthorn vinegar samples exhibited anticancer effects in cell culture experiments. In experiments on A549 (lung), MCF-7 (breast) and HT-29 (colon) cancer cell lines, ultrasound-treated vinegar increased apoptotic effects, suppressed cell migration and reduced necrosis rates in some cell lines. In particular, ultrasound treatment of vinegar resulted in a reduction in the expression of anti-apoptotic genes (BCL-2 and XIAP) and an enhancement in the expression of pro-apoptotic genes (BAX). These findings suggest that ultrasound technology preserves and enhances the bioactive components of hawthorn vinegar, improves its anticancer properties and increases its potential for use as a functional food product. |
| format | Article |
| id | doaj-art-f79fdd1b2a6f475299bb57880c5f31f8 |
| institution | Kabale University |
| issn | 1350-4177 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ultrasonics Sonochemistry |
| spelling | doaj-art-f79fdd1b2a6f475299bb57880c5f31f82025-01-30T05:13:48ZengElsevierUltrasonics Sonochemistry1350-41772025-03-01114107245Ultrasound-assisted enhancement of bioactive compounds in hawthorn vinegar: A functional approach to anticancer and antidiabetic effectsSelim Öğüt0Melikenur Türkol1Seydi Yıkmış2Esra Bozgeyik3Gholamreza Abdi4Emine Kocyigit5Rana Muhammad Aadil6Nilay Seyidoglu7Deniz Karakçı8Nazlı Tokatlı9Department of Biophysics, Faculty of Medicine, Bandırma Onyedi Eylul University 10250 Bandırma, Balıkesir, TürkiyeDepartment of Nutrition and Dietetics, Faculty of Health Sciences, Tekirdag Namık Kemal University 59030 Tekirdag, Türkiye; Corresponding authors.Department of Food Technology, Tekirdag Namık Kemal University 59830 Tekirdag, Türkiye; Corresponding authors.Department of Medical Biology, Faculty of Medicine, Adiyaman University, 02200, Adiyaman, TürkiyeDepartment of Biotechnology, Persian Gulf Research Institute, Persian Gulf University, Bushehr, 75169, Iran; Corresponding authors.Nutrition and Dietetics, Faculty of Health Sciences, Ordu University 52200 Ordu, TürkiyeNational Institute of Food Science and Technology, University of Agriculture, Faisalabad 38000 PakistanDepartment of Physiology, Faculty of Veterinary Medicine, Tekirdag Namik Kemal University 59030 Tekirdag, TürkiyeDepartment of Biochemistry, Faculty of Veterinary Medicine, Tekirdag Namik Kemal University 59030 Tekirdag, TürkiyeDepartment of Computer Engineering, Faculty of Engineering and Natural Sciences, Istanbul Health and Technology University 34421 Istanbul, TürkiyeIn this study, the effects of ultrasound treatment on bioactive components and functional properties of hawthorn vinegar (Crataegus tanacetifolia) were investigated. Parameters such as total phenolic compound (TPC), total flavonoid content (TFC), ascorbic acid (AA), DPPH radical scavenging activity and CUPRAC reducing capacity were optimised by surface response method (RSM) and 14 min duration and 61.40 % amplitude were determined as the most suitable treatment conditions. The results showed that ultrasound treatment improved the antioxidant properties of hawthorn vinegar by increasing TPC, TFC, DPPH and CUPRAC values. In addition, it was observed that hawthorn vinegar samples exhibited anticancer effects in cell culture experiments. In experiments on A549 (lung), MCF-7 (breast) and HT-29 (colon) cancer cell lines, ultrasound-treated vinegar increased apoptotic effects, suppressed cell migration and reduced necrosis rates in some cell lines. In particular, ultrasound treatment of vinegar resulted in a reduction in the expression of anti-apoptotic genes (BCL-2 and XIAP) and an enhancement in the expression of pro-apoptotic genes (BAX). These findings suggest that ultrasound technology preserves and enhances the bioactive components of hawthorn vinegar, improves its anticancer properties and increases its potential for use as a functional food product.http://www.sciencedirect.com/science/article/pii/S1350417725000240Ultrasound processingHawthorn vinegarBioactive compoundsAnticancer propertiesAntidiabetic effects |
| spellingShingle | Selim Öğüt Melikenur Türkol Seydi Yıkmış Esra Bozgeyik Gholamreza Abdi Emine Kocyigit Rana Muhammad Aadil Nilay Seyidoglu Deniz Karakçı Nazlı Tokatlı Ultrasound-assisted enhancement of bioactive compounds in hawthorn vinegar: A functional approach to anticancer and antidiabetic effects Ultrasonics Sonochemistry Ultrasound processing Hawthorn vinegar Bioactive compounds Anticancer properties Antidiabetic effects |
| title | Ultrasound-assisted enhancement of bioactive compounds in hawthorn vinegar: A functional approach to anticancer and antidiabetic effects |
| title_full | Ultrasound-assisted enhancement of bioactive compounds in hawthorn vinegar: A functional approach to anticancer and antidiabetic effects |
| title_fullStr | Ultrasound-assisted enhancement of bioactive compounds in hawthorn vinegar: A functional approach to anticancer and antidiabetic effects |
| title_full_unstemmed | Ultrasound-assisted enhancement of bioactive compounds in hawthorn vinegar: A functional approach to anticancer and antidiabetic effects |
| title_short | Ultrasound-assisted enhancement of bioactive compounds in hawthorn vinegar: A functional approach to anticancer and antidiabetic effects |
| title_sort | ultrasound assisted enhancement of bioactive compounds in hawthorn vinegar a functional approach to anticancer and antidiabetic effects |
| topic | Ultrasound processing Hawthorn vinegar Bioactive compounds Anticancer properties Antidiabetic effects |
| url | http://www.sciencedirect.com/science/article/pii/S1350417725000240 |
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