Predictors of Major Bleeding and Mortality in Dengue Infection: A Retrospective Observational Study in a Tertiary Care Centre in South India
We conducted a retrospective observational study to describe the clinical profile and outcomes of patients admitted with a diagnosis of dengue fever in a tertiary hospital in South India. A total of 159 patients admitted from April 2014 to October 2018 were included in the study. Vomiting (70.4%), m...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Series: | Interdisciplinary Perspectives on Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2019/4823791 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832548649237741568 |
|---|---|
| author | Kevin John John Karthik Gunasekaran John Davis Prasad Divya Mathew Sohini Das N. Sultan Asha Mary Abraham Ramya Iyyadurai |
| author_facet | Kevin John John Karthik Gunasekaran John Davis Prasad Divya Mathew Sohini Das N. Sultan Asha Mary Abraham Ramya Iyyadurai |
| author_sort | Kevin John John |
| collection | DOAJ |
| description | We conducted a retrospective observational study to describe the clinical profile and outcomes of patients admitted with a diagnosis of dengue fever in a tertiary hospital in South India. A total of 159 patients admitted from April 2014 to October 2018 were included in the study. Vomiting (70.4%), myalgia (60.4%), headache (42.1%), abdominal pain (38.4%), bleeding (38%), and rash (37.1%) were the most common symptoms at presentation. The mean duration of hospital stay was 4.9 days (SD ± 2.4), and the median cost was INR 19,708 ($285) (IQR INR 12,968–32,056 ($188–$305)). Major bleeding was associated with elevated SGOT and SGPT, severe dengue, and secondary dengue. Mortality was associated with elderly age; elevated total leukocyte count, serum bilirubin, serum creatinine, SGOT, and SGPT; and high SOFA score. In view of these observations, we recommend stratifying patients according to the WHO classification of dengue and avoiding the use of thrombocytopenia as a single marker of the severity of the illness. |
| format | Article |
| id | doaj-art-f764a8ccdac74fe89db4dfd77a600c57 |
| institution | Kabale University |
| issn | 1687-708X 1687-7098 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Interdisciplinary Perspectives on Infectious Diseases |
| spelling | doaj-art-f764a8ccdac74fe89db4dfd77a600c572025-02-03T06:13:29ZengWileyInterdisciplinary Perspectives on Infectious Diseases1687-708X1687-70982019-01-01201910.1155/2019/48237914823791Predictors of Major Bleeding and Mortality in Dengue Infection: A Retrospective Observational Study in a Tertiary Care Centre in South IndiaKevin John John0Karthik Gunasekaran1John Davis Prasad2Divya Mathew3Sohini Das4N. Sultan5Asha Mary Abraham6Ramya Iyyadurai7Department of Medicine, Christian Medical College, Vellore 632004, Tamil Nadu, IndiaDepartment of Medicine, Christian Medical College, Vellore 632004, Tamil Nadu, IndiaDepartment of Medicine, Christian Medical College, Vellore 632004, Tamil Nadu, IndiaDepartment of Medicine, Christian Medical College, Vellore 632004, Tamil Nadu, IndiaDepartment of Medicine, Christian Medical College, Vellore 632004, Tamil Nadu, IndiaDepartment of Medicine, Christian Medical College, Vellore 632004, Tamil Nadu, IndiaDepartment of Clinical Virology, Christian Medical College, Vellore 632004, Tamil Nadu, IndiaDepartment of Medicine, Christian Medical College, Vellore 632004, Tamil Nadu, IndiaWe conducted a retrospective observational study to describe the clinical profile and outcomes of patients admitted with a diagnosis of dengue fever in a tertiary hospital in South India. A total of 159 patients admitted from April 2014 to October 2018 were included in the study. Vomiting (70.4%), myalgia (60.4%), headache (42.1%), abdominal pain (38.4%), bleeding (38%), and rash (37.1%) were the most common symptoms at presentation. The mean duration of hospital stay was 4.9 days (SD ± 2.4), and the median cost was INR 19,708 ($285) (IQR INR 12,968–32,056 ($188–$305)). Major bleeding was associated with elevated SGOT and SGPT, severe dengue, and secondary dengue. Mortality was associated with elderly age; elevated total leukocyte count, serum bilirubin, serum creatinine, SGOT, and SGPT; and high SOFA score. In view of these observations, we recommend stratifying patients according to the WHO classification of dengue and avoiding the use of thrombocytopenia as a single marker of the severity of the illness.http://dx.doi.org/10.1155/2019/4823791 |
| spellingShingle | Kevin John John Karthik Gunasekaran John Davis Prasad Divya Mathew Sohini Das N. Sultan Asha Mary Abraham Ramya Iyyadurai Predictors of Major Bleeding and Mortality in Dengue Infection: A Retrospective Observational Study in a Tertiary Care Centre in South India Interdisciplinary Perspectives on Infectious Diseases |
| title | Predictors of Major Bleeding and Mortality in Dengue Infection: A Retrospective Observational Study in a Tertiary Care Centre in South India |
| title_full | Predictors of Major Bleeding and Mortality in Dengue Infection: A Retrospective Observational Study in a Tertiary Care Centre in South India |
| title_fullStr | Predictors of Major Bleeding and Mortality in Dengue Infection: A Retrospective Observational Study in a Tertiary Care Centre in South India |
| title_full_unstemmed | Predictors of Major Bleeding and Mortality in Dengue Infection: A Retrospective Observational Study in a Tertiary Care Centre in South India |
| title_short | Predictors of Major Bleeding and Mortality in Dengue Infection: A Retrospective Observational Study in a Tertiary Care Centre in South India |
| title_sort | predictors of major bleeding and mortality in dengue infection a retrospective observational study in a tertiary care centre in south india |
| url | http://dx.doi.org/10.1155/2019/4823791 |
| work_keys_str_mv | AT kevinjohnjohn predictorsofmajorbleedingandmortalityindengueinfectionaretrospectiveobservationalstudyinatertiarycarecentreinsouthindia AT karthikgunasekaran predictorsofmajorbleedingandmortalityindengueinfectionaretrospectiveobservationalstudyinatertiarycarecentreinsouthindia AT johndavisprasad predictorsofmajorbleedingandmortalityindengueinfectionaretrospectiveobservationalstudyinatertiarycarecentreinsouthindia AT divyamathew predictorsofmajorbleedingandmortalityindengueinfectionaretrospectiveobservationalstudyinatertiarycarecentreinsouthindia AT sohinidas predictorsofmajorbleedingandmortalityindengueinfectionaretrospectiveobservationalstudyinatertiarycarecentreinsouthindia AT nsultan predictorsofmajorbleedingandmortalityindengueinfectionaretrospectiveobservationalstudyinatertiarycarecentreinsouthindia AT ashamaryabraham predictorsofmajorbleedingandmortalityindengueinfectionaretrospectiveobservationalstudyinatertiarycarecentreinsouthindia AT ramyaiyyadurai predictorsofmajorbleedingandmortalityindengueinfectionaretrospectiveobservationalstudyinatertiarycarecentreinsouthindia |