Induced Pluripotent Stem Cells and Outer Retinal Disease
The retina, which is composed of multiple layers of differing cell types, has been considered the first choice for gene therapy, disease modeling, and stem cell-derived retinal cell transplant therapy. Because of its special characteristics, the retina, located in the posterior part of the eye, can...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/2850873 |
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| _version_ | 1832552540765421568 |
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| author | Jin Yang Bingcui Cai Patrick Glencer Zhiqing Li Xiaomin Zhang Xiaorong Li |
| author_facet | Jin Yang Bingcui Cai Patrick Glencer Zhiqing Li Xiaomin Zhang Xiaorong Li |
| author_sort | Jin Yang |
| collection | DOAJ |
| description | The retina, which is composed of multiple layers of differing cell types, has been considered the first choice for gene therapy, disease modeling, and stem cell-derived retinal cell transplant therapy. Because of its special characteristics, the retina, located in the posterior part of the eye, can be well observed directly after gene therapy or transplantation. The blood-retinal barrier is part of a specialized ocular microenvironment that is immune privileged. This protects transplanted cells and tissue. Having two eyes makes perfect natural control possible after a single eye receives gene or stem cell therapy. For this reason, research about exploring retinal diseases’ underlying molecular mechanisms and potential therapeutic approach using stem cell technique has been developing rapidly. This review is to present an up-to-date summary of the iPSC’s sources, variations, differentiation methods, and the wide-ranging application of iPSCs-RPCS or iPSCs-RPE on retinal disease modeling, diagnostics, and therapeutics. |
| format | Article |
| id | doaj-art-f7513b727e3548dbb97039ba93b6988b |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-f7513b727e3548dbb97039ba93b6988b2025-02-03T05:58:29ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/28508732850873Induced Pluripotent Stem Cells and Outer Retinal DiseaseJin Yang0Bingcui Cai1Patrick Glencer2Zhiqing Li3Xiaomin Zhang4Xiaorong Li5Tianjin Medical University Eye Hospital, Tianjin 300384, ChinaTianjin Medical University Eye Hospital, Tianjin 300384, ChinaNova Southeastern College of Optometry, Fort Lauderdale, FL 33314, USATianjin Medical University Eye Hospital, Tianjin 300384, ChinaTianjin Medical University Eye Hospital, Tianjin 300384, ChinaTianjin Medical University Eye Hospital, Tianjin 300384, ChinaThe retina, which is composed of multiple layers of differing cell types, has been considered the first choice for gene therapy, disease modeling, and stem cell-derived retinal cell transplant therapy. Because of its special characteristics, the retina, located in the posterior part of the eye, can be well observed directly after gene therapy or transplantation. The blood-retinal barrier is part of a specialized ocular microenvironment that is immune privileged. This protects transplanted cells and tissue. Having two eyes makes perfect natural control possible after a single eye receives gene or stem cell therapy. For this reason, research about exploring retinal diseases’ underlying molecular mechanisms and potential therapeutic approach using stem cell technique has been developing rapidly. This review is to present an up-to-date summary of the iPSC’s sources, variations, differentiation methods, and the wide-ranging application of iPSCs-RPCS or iPSCs-RPE on retinal disease modeling, diagnostics, and therapeutics.http://dx.doi.org/10.1155/2016/2850873 |
| spellingShingle | Jin Yang Bingcui Cai Patrick Glencer Zhiqing Li Xiaomin Zhang Xiaorong Li Induced Pluripotent Stem Cells and Outer Retinal Disease Stem Cells International |
| title | Induced Pluripotent Stem Cells and Outer Retinal Disease |
| title_full | Induced Pluripotent Stem Cells and Outer Retinal Disease |
| title_fullStr | Induced Pluripotent Stem Cells and Outer Retinal Disease |
| title_full_unstemmed | Induced Pluripotent Stem Cells and Outer Retinal Disease |
| title_short | Induced Pluripotent Stem Cells and Outer Retinal Disease |
| title_sort | induced pluripotent stem cells and outer retinal disease |
| url | http://dx.doi.org/10.1155/2016/2850873 |
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