Probing the functional constraints of influenza A virus NEP by deep mutational scanning

Probing the functional constraints of influenza A virus NEP by deep mutational scanning

Summary: The influenza A virus nuclear export protein (NEP) is a multifunctional protein that is essential for the viral life cycle and has very high sequence conservation. However, since the open reading frame of NEP largely overlaps with that of another influenza viral protein, non-structural prot...

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Bibliographic Details
Main Authors: Qi Wen Teo, Yiquan Wang, Huibin Lv, Michael S. Oade, Kevin J. Mao, Timothy J.C. Tan, Yang Wei Huan, Joel Rivera-Cardona, Evan K. Shao, Danbi Choi, Chaoyang Wang, Zahra Tavakoli Dargani, Christopher B. Brooke, Aartjan J.W. te Velthuis, Nicholas C. Wu
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Cell Reports
Subjects:
CP: Microbiology
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472401547X
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