Synthesis of 11-(Piperazin-1-yl)-5H-dibenzo[b,e] [1,4]diazepine on Kilo Scale
A synthesis of 11-(piperazin-1yl)-5 H-dibenzo[b,e][1,4]diazepine on kilo scale without any chromatographic purification step is reported. Key steps involved are Ullmann condensation, catalytic hydrogenation, and catalyzed cyclization.
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2011/212014 |
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| _version_ | 1832567275452891136 |
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| author | Rahul S. Kalhapure Bhushan P. Patil Mahantesh N. Jadhav Laxmikant A. Kawle Sanjay B. Wagh |
| author_facet | Rahul S. Kalhapure Bhushan P. Patil Mahantesh N. Jadhav Laxmikant A. Kawle Sanjay B. Wagh |
| author_sort | Rahul S. Kalhapure |
| collection | DOAJ |
| description | A synthesis of 11-(piperazin-1yl)-5 H-dibenzo[b,e][1,4]diazepine on kilo scale without any chromatographic purification step is reported. Key steps involved are Ullmann condensation, catalytic hydrogenation, and catalyzed cyclization. |
| format | Article |
| id | doaj-art-f73a0701319d44a393450f12e66c17de |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-f73a0701319d44a393450f12e66c17de2025-02-03T01:02:02ZengWileyE-Journal of Chemistry0973-49452090-98102011-01-01841747174910.1155/2011/212014Synthesis of 11-(Piperazin-1-yl)-5H-dibenzo[b,e] [1,4]diazepine on Kilo ScaleRahul S. Kalhapure0Bhushan P. Patil1Mahantesh N. Jadhav2Laxmikant A. Kawle3Sanjay B. Wagh4Dept. of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Matunga (East), Mumbai-400019, IndiaN.D.M.V.P.Samaj's College of Pharmacy, Gangapur Road, Nashik-422005, IndiaN.D.M.V.P.Samaj's College of Pharmacy, Gangapur Road, Nashik-422005, IndiaN.D.M.V.P.Samaj's College of Pharmacy, Gangapur Road, Nashik-422005, IndiaN.D.M.V.P.Samaj's College of Pharmacy, Gangapur Road, Nashik-422005, IndiaA synthesis of 11-(piperazin-1yl)-5 H-dibenzo[b,e][1,4]diazepine on kilo scale without any chromatographic purification step is reported. Key steps involved are Ullmann condensation, catalytic hydrogenation, and catalyzed cyclization.http://dx.doi.org/10.1155/2011/212014 |
| spellingShingle | Rahul S. Kalhapure Bhushan P. Patil Mahantesh N. Jadhav Laxmikant A. Kawle Sanjay B. Wagh Synthesis of 11-(Piperazin-1-yl)-5H-dibenzo[b,e] [1,4]diazepine on Kilo Scale E-Journal of Chemistry |
| title | Synthesis of 11-(Piperazin-1-yl)-5H-dibenzo[b,e] [1,4]diazepine on Kilo Scale |
| title_full | Synthesis of 11-(Piperazin-1-yl)-5H-dibenzo[b,e] [1,4]diazepine on Kilo Scale |
| title_fullStr | Synthesis of 11-(Piperazin-1-yl)-5H-dibenzo[b,e] [1,4]diazepine on Kilo Scale |
| title_full_unstemmed | Synthesis of 11-(Piperazin-1-yl)-5H-dibenzo[b,e] [1,4]diazepine on Kilo Scale |
| title_short | Synthesis of 11-(Piperazin-1-yl)-5H-dibenzo[b,e] [1,4]diazepine on Kilo Scale |
| title_sort | synthesis of 11 piperazin 1 yl 5h dibenzo b e 1 4 diazepine on kilo scale |
| url | http://dx.doi.org/10.1155/2011/212014 |
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