Glucosylated cholesterol accumulates in atherosclerotic lesions and impacts macrophage immune response

Glucosylated cholesterol accumulates in atherosclerotic lesions and impacts macrophage immune response

Atherosclerosis can be described as a local acquired lysosomal storage disorder (LSD), resulting from the build-up of undegraded material in lysosomes. Atherosclerotic foam cells accumulate cholesterol (Chol) and glycosphingolipids (GSLs) within lysosomes. This constitutes the ideal milieu for the f...

Full description

Saved in:
Bibliographic Details
Main Authors: André R.A. Marques, Inês S. Ferreira, Quélia Ribeiro, Maria J. Ferraz, Elizeth Lopes, Daniela Pinto, Michael Hall, José Ramalho, Marta Artola, Manuel S. Almeida, Gustavo Rodrigues, Pedro Araújo Gonçalves, Jorge Ferreira, Cláudia Borbinha, João Pedro Marto, Miguel Viana-Baptista, Ryan Gouveia e Melo, Luís Mendes Pedro, Maria I.L. Soares, Winchil L.C. Vaz, Otília V. Vieira, Johannes M.F.G. Aerts
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Journal of Lipid Research
Subjects:
glucosylated cholesterol
glycosphingolipids
macrophage
multinucleated cells
lysosome
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227525000859
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

http://www.sciencedirect.com/science/article/pii/S0022227525000859

Similar Items