Sub-inhibitory concentrations of tigecycline could attenuate the virulence of Staphylococcus aureus by inhibiting the product of α-toxin

Sub-inhibitory concentrations of tigecycline could attenuate the virulence of Staphylococcus aureus by inhibiting the product of α-toxin

ABSTRACT Staphylococcus aureus (S. aureus) infection is a serious threat to global health. This study aimed to investigate the anti-virulence efficacy of tigecycline against S. aureus. We used highly virulent S. aureus strains SA75 and JP30 to evaluate the effect of tigecycline on virulence, both of...

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Bibliographic Details
Main Authors: Junhong Shi, Li Shen, Yanghua Xiao, Cailing Wan, Bingjie Wang, Peiyao Zhou, Jiao Zhang, Weihua Han, Fangyou Yu
Format: Article
Language:English
Published: American Society for Microbiology 2025-05-01
Series:Microbiology Spectrum
Subjects:
Staphylococcus aureus
tigecycline
virulence
α-toxin
SaeRS two-component system
host immune response
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01344-24
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https://journals.asm.org/doi/10.1128/spectrum.01344-24

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