Production of SARS-CoV-2 virus-like particles as a vaccine candidate in stable cell lines through inducible E and M protein expression

Production of SARS-CoV-2 virus-like particles as a vaccine candidate in stable cell lines through inducible E and M protein expression

Abstract Virus-like particles (VLPs) offer potentially high-immunogenicity/low-cost vaccine platforms. SARS-CoV-2 VLPs production is achieved via transient transfection of genes encoding viral structural proteins, but is costly and difficult to scale up. To address this problem, stable VLPs-producin...

Full description

Saved in:
Bibliographic Details
Main Authors: Yu Liu, Zhian Chen, Li Yang, Chunmei Gan, Jieshi Tang, Zhaoyue Zheng, JingYa Ye, C. Alexander Valencia, Hoi Yee Chow, Biao Dong
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Biotechnology
Subjects:
COVID-19
SARS-CoV-2
Virus-like particles
Stable cell line
Inducible expression
Vaccine
Online Access:https://doi.org/10.1186/s12896-025-01016-x
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1186/s12896-025-01016-x

Similar Items