Enhanced mitochondrial function and delivery from adipose-derived stem cell spheres via the EZH2-H3K27me3-PPARγ pathway for advanced therapy

Enhanced mitochondrial function and delivery from adipose-derived stem cell spheres via the EZH2-H3K27me3-PPARγ pathway for advanced therapy

Abstract Background Microenvironmental alterations induce significant genetic and epigenetic changes in stem cells. Mitochondria, essential for regenerative capabilities, provide the necessary energy for stem cell function. However, the specific roles of histone modifications and mitochondrial dynam...

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Main Authors: Ming-Min Chang, Dinh Toi Chu, Sheng-Che Lin, Jung-Shun Lee, Thuy Duong Vu, Hue Thi Vu, Thamil Selvee Ramasamy, Shau-Ping Lin, Chia-Ching Wu
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Stem Cell Research & Therapy
Subjects:
Enhanced mitochondrial function
Adipose-derived stem cells
3D spheroid culture
Chitosan nano-deposition
EZH2-H3K27me3-PPARγ pathway
Mitochondrial therapy
Online Access:https://doi.org/10.1186/s13287-025-04164-1
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https://doi.org/10.1186/s13287-025-04164-1

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