Repellents against Aedes aegypti bites: synthetic and natural origins
Dengue fever, transmitted by mosquitoes of the Aedes genus, particularly Aedes aegypti, has emerged as a global health issue. With the expansion of this mosquito to new geographical areas, driven by factors such as climate change, the need for preventive measures like using insect repellents has bec...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Insect Science |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/finsc.2024.1510857/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832591345120706560 |
|---|---|
| author | Melissa Noguera-Gahona Cindy Peña-Moreno Natalia Quiñones-Sobarzo Natalia Quiñones-Sobarzo Caroline Weinstein-Oppenheimer Caroline Weinstein-Oppenheimer María Guerra-Zúñiga Ximena Collao-Ferrada Ximena Collao-Ferrada |
| author_facet | Melissa Noguera-Gahona Cindy Peña-Moreno Natalia Quiñones-Sobarzo Natalia Quiñones-Sobarzo Caroline Weinstein-Oppenheimer Caroline Weinstein-Oppenheimer María Guerra-Zúñiga Ximena Collao-Ferrada Ximena Collao-Ferrada |
| author_sort | Melissa Noguera-Gahona |
| collection | DOAJ |
| description | Dengue fever, transmitted by mosquitoes of the Aedes genus, particularly Aedes aegypti, has emerged as a global health issue. With the expansion of this mosquito to new geographical areas, driven by factors such as climate change, the need for preventive measures like using insect repellents has become critical. The present review explores the current state of the art on topical mosquito repellents, both synthetic and natural, used globally, especially in regions where dengue is endemic. Among synthetic repellents, DEET is the most widely used, supported by investigations demonstrating its efficacy and safety, although concerns about its toxicity exist in exceptional cases. Other compounds, such as picaridin, IR3535, and PMD are also common and offer alternatives with variable safety and efficacy profiles. Natural repellents, such as essential oils of citronella, lemon eucalyptus, and clove, have proven effective against Aedes aegypti. However, they present challenges due to rapid volatilization and the limited duration of their protective effect. To address these issues, combinations of essential oils and synthetic compounds have been proposed to improve efficacy and safety. Finally, the review highlights the complexity and the challenges of developing new repellents, including the high costs and lengthy timelines for commercialization, as well as the importance of continued research to improve the efficacy and safety of these products. |
| format | Article |
| id | doaj-art-f65bcd5ef017483db8f35d192921d4c9 |
| institution | Kabale University |
| issn | 2673-8600 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Insect Science |
| spelling | doaj-art-f65bcd5ef017483db8f35d192921d4c92025-01-22T13:53:46ZengFrontiers Media S.A.Frontiers in Insect Science2673-86002025-01-01410.3389/finsc.2024.15108571510857Repellents against Aedes aegypti bites: synthetic and natural originsMelissa Noguera-Gahona0Cindy Peña-Moreno1Natalia Quiñones-Sobarzo2Natalia Quiñones-Sobarzo3Caroline Weinstein-Oppenheimer4Caroline Weinstein-Oppenheimer5María Guerra-Zúñiga6Ximena Collao-Ferrada7Ximena Collao-Ferrada8Virología, Laboratorio Clínico, Facultad de Medicina, Universidad de Valparaíso, Viña del mar, ChileVirología, Laboratorio Clínico, Facultad de Medicina, Universidad de Valparaíso, Viña del mar, ChileFacultad de Farmacia, Universidad de Valparaíso, Valparaíso, ChileCentro de Investigación, Desarrollo e Innovación en Productos Bioactivos, Universidad de Valparaíso, Valparaíso, ChileFacultad de Farmacia, Universidad de Valparaíso, Valparaíso, ChileCentro de Investigación, Desarrollo e Innovación en Productos Bioactivos, Universidad de Valparaíso, Valparaíso, ChileDepartamento de Salud Pública, Facultad de Medicina, Universidad de Valparaíso, Viña del mar, ChileVirología, Laboratorio Clínico, Facultad de Medicina, Universidad de Valparaíso, Viña del mar, ChileCentro Interdisciplinario de Investigación Biomédica e Ingeniería para la salud, Universidad de Valparaíso, Viña del mar, ChileDengue fever, transmitted by mosquitoes of the Aedes genus, particularly Aedes aegypti, has emerged as a global health issue. With the expansion of this mosquito to new geographical areas, driven by factors such as climate change, the need for preventive measures like using insect repellents has become critical. The present review explores the current state of the art on topical mosquito repellents, both synthetic and natural, used globally, especially in regions where dengue is endemic. Among synthetic repellents, DEET is the most widely used, supported by investigations demonstrating its efficacy and safety, although concerns about its toxicity exist in exceptional cases. Other compounds, such as picaridin, IR3535, and PMD are also common and offer alternatives with variable safety and efficacy profiles. Natural repellents, such as essential oils of citronella, lemon eucalyptus, and clove, have proven effective against Aedes aegypti. However, they present challenges due to rapid volatilization and the limited duration of their protective effect. To address these issues, combinations of essential oils and synthetic compounds have been proposed to improve efficacy and safety. Finally, the review highlights the complexity and the challenges of developing new repellents, including the high costs and lengthy timelines for commercialization, as well as the importance of continued research to improve the efficacy and safety of these products.https://www.frontiersin.org/articles/10.3389/finsc.2024.1510857/fullrepellent activitysynthetic repellentsnatural repellentsarboviruses emergencedengue prevention strategy |
| spellingShingle | Melissa Noguera-Gahona Cindy Peña-Moreno Natalia Quiñones-Sobarzo Natalia Quiñones-Sobarzo Caroline Weinstein-Oppenheimer Caroline Weinstein-Oppenheimer María Guerra-Zúñiga Ximena Collao-Ferrada Ximena Collao-Ferrada Repellents against Aedes aegypti bites: synthetic and natural origins Frontiers in Insect Science repellent activity synthetic repellents natural repellents arboviruses emergence dengue prevention strategy |
| title | Repellents against Aedes aegypti bites: synthetic and natural origins |
| title_full | Repellents against Aedes aegypti bites: synthetic and natural origins |
| title_fullStr | Repellents against Aedes aegypti bites: synthetic and natural origins |
| title_full_unstemmed | Repellents against Aedes aegypti bites: synthetic and natural origins |
| title_short | Repellents against Aedes aegypti bites: synthetic and natural origins |
| title_sort | repellents against aedes aegypti bites synthetic and natural origins |
| topic | repellent activity synthetic repellents natural repellents arboviruses emergence dengue prevention strategy |
| url | https://www.frontiersin.org/articles/10.3389/finsc.2024.1510857/full |
| work_keys_str_mv | AT melissanogueragahona repellentsagainstaedesaegyptibitessyntheticandnaturalorigins AT cindypenamoreno repellentsagainstaedesaegyptibitessyntheticandnaturalorigins AT nataliaquinonessobarzo repellentsagainstaedesaegyptibitessyntheticandnaturalorigins AT nataliaquinonessobarzo repellentsagainstaedesaegyptibitessyntheticandnaturalorigins AT carolineweinsteinoppenheimer repellentsagainstaedesaegyptibitessyntheticandnaturalorigins AT carolineweinsteinoppenheimer repellentsagainstaedesaegyptibitessyntheticandnaturalorigins AT mariaguerrazuniga repellentsagainstaedesaegyptibitessyntheticandnaturalorigins AT ximenacollaoferrada repellentsagainstaedesaegyptibitessyntheticandnaturalorigins AT ximenacollaoferrada repellentsagainstaedesaegyptibitessyntheticandnaturalorigins |