Arterial Calcium Stimulation with Hepatic Venous Sampling in the Localization Diagnosis of Endogenous Hyperinsulinism
Objective. The aim of this study was to assess the utility of arterial calcium stimulation with hepatic venous sampling (ASVS) in the localization diagnosis of endogenous hyperinsulinism. Patients and Methods. A retrospective descriptive study was performed including patients with endogenous hyperin...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2016/4581094 |
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| author | Paloma Moreno-Moreno María Rosa Alhambra-Expósito Aura Dulcinea Herrera-Martínez Rafel Palomares-Ortega Luis Zurera-Tendero Juan José Espejo Herrero María Angeles Gálvez-Moreno |
| author_facet | Paloma Moreno-Moreno María Rosa Alhambra-Expósito Aura Dulcinea Herrera-Martínez Rafel Palomares-Ortega Luis Zurera-Tendero Juan José Espejo Herrero María Angeles Gálvez-Moreno |
| author_sort | Paloma Moreno-Moreno |
| collection | DOAJ |
| description | Objective. The aim of this study was to assess the utility of arterial calcium stimulation with hepatic venous sampling (ASVS) in the localization diagnosis of endogenous hyperinsulinism. Patients and Methods. A retrospective descriptive study was performed including patients with endogenous hyperinsulinism who underwent ASVS. The histopathological diagnosis in patients who underwent a surgical procedure was used as the reference for the statistical study of the accuracy of this technique. Results. 30 patients were included with endogenous hyperinsulinism and nonconclusive imaging diagnosis was included. ASVS was performed in all cases. Surgery was performed in 20 cases. Insulinoma was removed in 19 patients; the location of all cases was detected in the ASVS. All cases of endogenous hyperinsulinism had a positive result for the ASVS, with this association being statistically significant (χ2=15.771; p<0.001). A good and statistically significant agreement was obtained between histopathologic diagnosis and ASVS results (K=0.518, p<0.001). Conclusions. ASVS is a useful procedure in the localization diagnosis of endogenous hyperinsulinism undetected by other imaging tests. This technique allows the localization of intrapancreatic insulinomas and represents useful tool for the diagnosis and surgical management of these tumors. |
| format | Article |
| id | doaj-art-f63c8a6c20eb410e8cc9952c33388676 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-f63c8a6c20eb410e8cc9952c333886762025-02-03T01:29:17ZengWileyInternational Journal of Endocrinology1687-83371687-83452016-01-01201610.1155/2016/45810944581094Arterial Calcium Stimulation with Hepatic Venous Sampling in the Localization Diagnosis of Endogenous HyperinsulinismPaloma Moreno-Moreno0María Rosa Alhambra-Expósito1Aura Dulcinea Herrera-Martínez2Rafel Palomares-Ortega3Luis Zurera-Tendero4Juan José Espejo Herrero5María Angeles Gálvez-Moreno6Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), Córdoba, SpainMaimonides Institute for Biomedical Research of Cordoba (IMIBIC), Córdoba, SpainMaimonides Institute for Biomedical Research of Cordoba (IMIBIC), Córdoba, SpainEndocrinology and Nutrition Service, Reina Sofia University Hospital, Córdoba, SpainRadiology Department, Reina Sofia University Hospital, Córdoba, SpainRadiology Department, Reina Sofia University Hospital, Córdoba, SpainMaimonides Institute for Biomedical Research of Cordoba (IMIBIC), Córdoba, SpainObjective. The aim of this study was to assess the utility of arterial calcium stimulation with hepatic venous sampling (ASVS) in the localization diagnosis of endogenous hyperinsulinism. Patients and Methods. A retrospective descriptive study was performed including patients with endogenous hyperinsulinism who underwent ASVS. The histopathological diagnosis in patients who underwent a surgical procedure was used as the reference for the statistical study of the accuracy of this technique. Results. 30 patients were included with endogenous hyperinsulinism and nonconclusive imaging diagnosis was included. ASVS was performed in all cases. Surgery was performed in 20 cases. Insulinoma was removed in 19 patients; the location of all cases was detected in the ASVS. All cases of endogenous hyperinsulinism had a positive result for the ASVS, with this association being statistically significant (χ2=15.771; p<0.001). A good and statistically significant agreement was obtained between histopathologic diagnosis and ASVS results (K=0.518, p<0.001). Conclusions. ASVS is a useful procedure in the localization diagnosis of endogenous hyperinsulinism undetected by other imaging tests. This technique allows the localization of intrapancreatic insulinomas and represents useful tool for the diagnosis and surgical management of these tumors.http://dx.doi.org/10.1155/2016/4581094 |
| spellingShingle | Paloma Moreno-Moreno María Rosa Alhambra-Expósito Aura Dulcinea Herrera-Martínez Rafel Palomares-Ortega Luis Zurera-Tendero Juan José Espejo Herrero María Angeles Gálvez-Moreno Arterial Calcium Stimulation with Hepatic Venous Sampling in the Localization Diagnosis of Endogenous Hyperinsulinism International Journal of Endocrinology |
| title | Arterial Calcium Stimulation with Hepatic Venous Sampling in the Localization Diagnosis of Endogenous Hyperinsulinism |
| title_full | Arterial Calcium Stimulation with Hepatic Venous Sampling in the Localization Diagnosis of Endogenous Hyperinsulinism |
| title_fullStr | Arterial Calcium Stimulation with Hepatic Venous Sampling in the Localization Diagnosis of Endogenous Hyperinsulinism |
| title_full_unstemmed | Arterial Calcium Stimulation with Hepatic Venous Sampling in the Localization Diagnosis of Endogenous Hyperinsulinism |
| title_short | Arterial Calcium Stimulation with Hepatic Venous Sampling in the Localization Diagnosis of Endogenous Hyperinsulinism |
| title_sort | arterial calcium stimulation with hepatic venous sampling in the localization diagnosis of endogenous hyperinsulinism |
| url | http://dx.doi.org/10.1155/2016/4581094 |
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