Cathepsin S regulates antitumor immunity through autophagic degradation of PD-L1 in colorectal cancer cells

Cathepsin S regulates antitumor immunity through autophagic degradation of PD-L1 in colorectal cancer cells

Abstract Colorectal cancer (CRC) is a major contributor to cancer-related mortality worldwide, highlighting the need to overcome its immunosuppressive tumor microenvironment. Cathepsin S (CTSS), a cysteine protease essential for MHC class II antigen presentation, has an unclear role in CRC immunity....

Full description

Saved in:
Bibliographic Details
Main Authors: Sina Taheri Baghmisheh, Chung-Hsing Chen, Yu-Min Yeh, Peng-Chan Lin, Po-Chuan Chen, Ren-Hao Chan, Jui-Wen Kang, Chung-Ta Lee, Hui-Ju Tsai, Yu-Chen Fang, Chun Hei Antonio Cheung, Kwang-Yu Chang, Jang-Yang Chang, Shang-Hung Chen
Format: Article
Language:English
Published: Springer 2025-08-01
Series:Cancer Immunology, Immunotherapy
Subjects:
CTSS
Colorectal cancer
Immune microenvironment
PD-L1
Autophagy
Online Access:https://doi.org/10.1007/s00262-025-04140-x
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1007/s00262-025-04140-x

Similar Items