Effectiveness of dolutegravir-based vs boosted darunavir-based first-line 3-drug regimens in people with HIV with advanced disease: A trial emulation

Effectiveness of dolutegravir-based vs boosted darunavir-based first-line 3-drug regimens in people with HIV with advanced disease: A trial emulation

Background: No randomized comparisons exist between dolutegravir (DTG) and boosted-darunavir (DRV/b) for people initiating treatment with advanced HIV. Methods: Antiretroviral therapy (ART)-naïve people with HIV (PWH) with CD4 < 200 cells/mm3 or AIDS who started a first-line three-drug regimen wi...

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Main Authors: Roberta Gagliardini, Andrea Giacomelli, Cristina Mussini, Stephen R. Cole, Jessie K. Edwards, Carmela Pinnetti, Alessandro Raimondi, Spinello Antinori, Silvia Nozza, Valentina Mazzotta, Giulia Carla Marchetti, Sergio Lo Caputo, Alessandro Tavelli, Antonella d'Arminio Monforte, Andrea Antinori, Alessandro Cozzi-Lepri
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:International Journal of Infectious Diseases
Subjects:
ART-naïve
Integrase inhibitors
Antiretroviral therapy
AIDS
Trial emulation
Online Access:http://www.sciencedirect.com/science/article/pii/S1201971225001067
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