Neural network analysis as a novel skin outcome in a trial of belumosudil in patients with systemic sclerosis

Neural network analysis as a novel skin outcome in a trial of belumosudil in patients with systemic sclerosis

Abstract Background The modified Rodnan skin score (mRSS), a measure of systemic sclerosis (SSc) skin thickness, is agnostic to inflammation and vasculopathy. Previously, we demonstrated the potential of neural network-based digital pathology applied to SSc skin biopsies as a quantitative outcome. H...

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Main Authors: Ilayda Gunes, Elana J. Bernstein, Shawn E. Cowper, Gauri Panse, Niki Pradhan, Lucy Duran Camacho, Nicolas Page, Elizabeth Bundschuh, Alyssa Williams, Mary Carns, Kathleen Aren, Sarah Fantus, Elizabeth R. Volkmann, Heather Bukiri, Chase Correia, Vijaya B. Kolachalama, F. Perry Wilson, Seamus Mawe, J. Matthew Mahoney, Monique Hinchcliff
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Arthritis Research & Therapy
Subjects:
Systemic sclerosis
Scleroderma
Modified Rodnan skin score
Deep Neural Network
AlexNet
Belumosudil
Online Access:https://doi.org/10.1186/s13075-025-03508-9
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https://doi.org/10.1186/s13075-025-03508-9

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