Mechanistic PKPD modeling to describe cytokine release associated with CD3 T-cell engager therapies

Mechanistic PKPD modeling to describe cytokine release associated with CD3 T-cell engager therapies

IntroductionT-cell engagers (TCE), a therapeutic class of cancer immunotherapy (CIT), offer a novel approach to cancer treatment by harnessing and reactivating the patient’s immune system to eradicate tumor cells. However, the use of TCE in the clinic can lead to severe side effects, including cytok...

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Bibliographic Details
Main Authors: Apolline Lefèvre, Zinnia P. Parra-Guillen, Iñaki F. Trocóniz, Christophe Boetsch, Nicolas Frances
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
cancer immunotherapy (CIT)
T-cell engager (TCE)
cytokine release
pharmacokinetics/pharmacodynamics (PK/PD) modeling
effector T-cell dynamics
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1463915/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1463915/full

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