Joint cell segmentation and cell type annotation for spatial transcriptomics

Abstract RNA hybridization‐based spatial transcriptomics provides unparalleled detection sensitivity. However, inaccuracies in segmentation of image volumes into cells cause misassignment of mRNAs which is a major source of errors. Here, we develop JSTA, a computational framework for joint cell segm...

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Bibliographic Details
Main Authors: Russell Littman, Zachary Hemminger, Robert Foreman, Douglas Arneson, Guanglin Zhang, Fernando Gómez‐Pinilla, Xia Yang, Roy Wollman
Format: Article
Language:English
Published: Springer Nature 2021-05-01
Series:Molecular Systems Biology
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Online Access:https://doi.org/10.15252/msb.202010108
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