Molecular Targets of Shenqi Dihuang, A Traditional Chinese Herbal Medicine, and Its Potential Role in Renal Cell Carcinoma Therapy
Chinese herbal medicine (CHM), which includes herbal slices and proprietary products, is widely used in China. Shenqi Dihuang (SQDH) is a traditional Chinese medicine (TCM) formula with ingredients that affect tumor growth. Despite recent advances in prognosis, patients with renal...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-01-01
|
| Series: | Genetics Research |
| Online Access: | http://dx.doi.org/10.1155/2023/2355891 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832549763552116736 |
|---|---|
| author | Xinglin Chen Tongtong Zhang Xiangyang Zhan Xinyue Zang Xinyu Zhai Zhong Wan Minyao Ge Mingyue Tan Jianyi Gu Dongliang Xu |
| author_facet | Xinglin Chen Tongtong Zhang Xiangyang Zhan Xinyue Zang Xinyu Zhai Zhong Wan Minyao Ge Mingyue Tan Jianyi Gu Dongliang Xu |
| author_sort | Xinglin Chen |
| collection | DOAJ |
| description | Chinese herbal medicine (CHM), which includes herbal slices and proprietary
products, is widely used in China. Shenqi Dihuang (SQDH) is a traditional
Chinese medicine (TCM) formula with ingredients that affect tumor growth.
Despite recent advances in prognosis, patients with renal cell carcinoma (RCC)
cannot currently receive curative treatment. The present study aimed to explore
the potential target genes closely associated with SQDH. The gene expression
data for SQDH and RCC were obtained from the TCMSP and TCGA databases. The
SQDH-based prognostic prediction model reveals a strong correlation between RCC
and SQDH. In addition, the immune cell infiltration analysis indicated that SQDH
might be associated with the immune response of RCC patients. Based on this, we
successfully built the prognostic prediction model using SQDH-related genes. The
results demonstrated that CCND1 and NR3C2 are closely associated with the
prognosis of RCC patients. Finally, the pathways enrichment analysis revealed
that response to oxidative stress, cyclin binding, programmed cell death, and
immune response are the most enriched pathways in CCND1. Furthermore,
transcription regulator activity, regulation of cell population proliferation,
and cyclin binding are closely associated with the NR3C2. |
| format | Article |
| id | doaj-art-f5d468d6c6b34289b636555a3e2f1ee5 |
| institution | Kabale University |
| issn | 1469-5073 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Genetics Research |
| spelling | doaj-art-f5d468d6c6b34289b636555a3e2f1ee52025-02-03T06:08:46ZengWileyGenetics Research1469-50732023-01-01202310.1155/2023/2355891Molecular Targets of Shenqi Dihuang, A Traditional Chinese Herbal Medicine, and Its Potential Role in Renal Cell Carcinoma TherapyXinglin Chen0Tongtong Zhang1Xiangyang Zhan2Xinyue Zang3Xinyu Zhai4Zhong Wan5Minyao Ge6Mingyue Tan7Jianyi Gu8Dongliang Xu9Urology CentreUrology CentreUrology CentreUrology CentreUrology CentreUrology CentreUrology CentreUrology CentreUrology CentreUrology CentreChinese herbal medicine (CHM), which includes herbal slices and proprietary products, is widely used in China. Shenqi Dihuang (SQDH) is a traditional Chinese medicine (TCM) formula with ingredients that affect tumor growth. Despite recent advances in prognosis, patients with renal cell carcinoma (RCC) cannot currently receive curative treatment. The present study aimed to explore the potential target genes closely associated with SQDH. The gene expression data for SQDH and RCC were obtained from the TCMSP and TCGA databases. The SQDH-based prognostic prediction model reveals a strong correlation between RCC and SQDH. In addition, the immune cell infiltration analysis indicated that SQDH might be associated with the immune response of RCC patients. Based on this, we successfully built the prognostic prediction model using SQDH-related genes. The results demonstrated that CCND1 and NR3C2 are closely associated with the prognosis of RCC patients. Finally, the pathways enrichment analysis revealed that response to oxidative stress, cyclin binding, programmed cell death, and immune response are the most enriched pathways in CCND1. Furthermore, transcription regulator activity, regulation of cell population proliferation, and cyclin binding are closely associated with the NR3C2.http://dx.doi.org/10.1155/2023/2355891 |
| spellingShingle | Xinglin Chen Tongtong Zhang Xiangyang Zhan Xinyue Zang Xinyu Zhai Zhong Wan Minyao Ge Mingyue Tan Jianyi Gu Dongliang Xu Molecular Targets of Shenqi Dihuang, A Traditional Chinese Herbal Medicine, and Its Potential Role in Renal Cell Carcinoma Therapy Genetics Research |
| title | Molecular Targets of Shenqi Dihuang, A Traditional Chinese Herbal
Medicine, and Its Potential Role in Renal Cell Carcinoma Therapy |
| title_full | Molecular Targets of Shenqi Dihuang, A Traditional Chinese Herbal
Medicine, and Its Potential Role in Renal Cell Carcinoma Therapy |
| title_fullStr | Molecular Targets of Shenqi Dihuang, A Traditional Chinese Herbal
Medicine, and Its Potential Role in Renal Cell Carcinoma Therapy |
| title_full_unstemmed | Molecular Targets of Shenqi Dihuang, A Traditional Chinese Herbal
Medicine, and Its Potential Role in Renal Cell Carcinoma Therapy |
| title_short | Molecular Targets of Shenqi Dihuang, A Traditional Chinese Herbal
Medicine, and Its Potential Role in Renal Cell Carcinoma Therapy |
| title_sort | molecular targets of shenqi dihuang a traditional chinese herbal medicine and its potential role in renal cell carcinoma therapy |
| url | http://dx.doi.org/10.1155/2023/2355891 |
| work_keys_str_mv | AT xinglinchen moleculartargetsofshenqidihuangatraditionalchineseherbalmedicineanditspotentialroleinrenalcellcarcinomatherapy AT tongtongzhang moleculartargetsofshenqidihuangatraditionalchineseherbalmedicineanditspotentialroleinrenalcellcarcinomatherapy AT xiangyangzhan moleculartargetsofshenqidihuangatraditionalchineseherbalmedicineanditspotentialroleinrenalcellcarcinomatherapy AT xinyuezang moleculartargetsofshenqidihuangatraditionalchineseherbalmedicineanditspotentialroleinrenalcellcarcinomatherapy AT xinyuzhai moleculartargetsofshenqidihuangatraditionalchineseherbalmedicineanditspotentialroleinrenalcellcarcinomatherapy AT zhongwan moleculartargetsofshenqidihuangatraditionalchineseherbalmedicineanditspotentialroleinrenalcellcarcinomatherapy AT minyaoge moleculartargetsofshenqidihuangatraditionalchineseherbalmedicineanditspotentialroleinrenalcellcarcinomatherapy AT mingyuetan moleculartargetsofshenqidihuangatraditionalchineseherbalmedicineanditspotentialroleinrenalcellcarcinomatherapy AT jianyigu moleculartargetsofshenqidihuangatraditionalchineseherbalmedicineanditspotentialroleinrenalcellcarcinomatherapy AT dongliangxu moleculartargetsofshenqidihuangatraditionalchineseherbalmedicineanditspotentialroleinrenalcellcarcinomatherapy |