Chronic Administration of 5-HT1A Receptor Agonist Relieves Depression and Depression-Induced Hypoalgesia
Previous studies have shown that depressed patients as well as animal models of depression exhibit decreased sensitivity to evoked pain stimuli, and serotonin is indicated to be involved in depression-induced hypoalgesia. The purpose of this study was to investigate the potential role of 5-HT1A rece...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/405736 |
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| author | Zhao-Cai Jiang Wei-Jing Qi Jin-Yan Wang Fei Luo |
| author_facet | Zhao-Cai Jiang Wei-Jing Qi Jin-Yan Wang Fei Luo |
| author_sort | Zhao-Cai Jiang |
| collection | DOAJ |
| description | Previous studies have shown that depressed patients as well as animal models of depression exhibit decreased sensitivity to evoked pain stimuli, and serotonin is indicated to be involved in depression-induced hypoalgesia. The purpose of this study was to investigate the potential role of 5-HT1A receptor in the depression-induced hypoalgesia. Acute or chronic administration of 5-HT1A receptor agonist, 8-OH-DPAT, was performed in olfactory bulbectomy (OB) and sham-operated rats. The depression-like behavior and pain thresholds were measured using open-field test and radiant heat thermal pain test, respectively. We found that acute administration of 8-OH-DPAT increased locomotor activity and pain thresholds in the sham rats but had no effect on the OB rats. In contrast, chronic administration of 8-OH-DPAT reduced locomotor activity and pain thresholds and restored them to normal level. Increased pain thresholds were also observed in the sham rats after the chronic administration. These results demonstrated that chronic administration of 8-OH-DPAT reversed the depression-induced decrease in pain sensitivity in rats, suggesting that 5-HT1A receptor may play a role in the depression-associated hypoalgesia. |
| format | Article |
| id | doaj-art-f5b304f261ce4f3db863798e580e52e9 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-f5b304f261ce4f3db863798e580e52e92025-02-03T01:12:56ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/405736405736Chronic Administration of 5-HT1A Receptor Agonist Relieves Depression and Depression-Induced HypoalgesiaZhao-Cai Jiang0Wei-Jing Qi1Jin-Yan Wang2Fei Luo3Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, ChinaKey Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, ChinaKey Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, ChinaKey Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, ChinaPrevious studies have shown that depressed patients as well as animal models of depression exhibit decreased sensitivity to evoked pain stimuli, and serotonin is indicated to be involved in depression-induced hypoalgesia. The purpose of this study was to investigate the potential role of 5-HT1A receptor in the depression-induced hypoalgesia. Acute or chronic administration of 5-HT1A receptor agonist, 8-OH-DPAT, was performed in olfactory bulbectomy (OB) and sham-operated rats. The depression-like behavior and pain thresholds were measured using open-field test and radiant heat thermal pain test, respectively. We found that acute administration of 8-OH-DPAT increased locomotor activity and pain thresholds in the sham rats but had no effect on the OB rats. In contrast, chronic administration of 8-OH-DPAT reduced locomotor activity and pain thresholds and restored them to normal level. Increased pain thresholds were also observed in the sham rats after the chronic administration. These results demonstrated that chronic administration of 8-OH-DPAT reversed the depression-induced decrease in pain sensitivity in rats, suggesting that 5-HT1A receptor may play a role in the depression-associated hypoalgesia.http://dx.doi.org/10.1155/2014/405736 |
| spellingShingle | Zhao-Cai Jiang Wei-Jing Qi Jin-Yan Wang Fei Luo Chronic Administration of 5-HT1A Receptor Agonist Relieves Depression and Depression-Induced Hypoalgesia The Scientific World Journal |
| title | Chronic Administration of 5-HT1A Receptor Agonist Relieves Depression and Depression-Induced Hypoalgesia |
| title_full | Chronic Administration of 5-HT1A Receptor Agonist Relieves Depression and Depression-Induced Hypoalgesia |
| title_fullStr | Chronic Administration of 5-HT1A Receptor Agonist Relieves Depression and Depression-Induced Hypoalgesia |
| title_full_unstemmed | Chronic Administration of 5-HT1A Receptor Agonist Relieves Depression and Depression-Induced Hypoalgesia |
| title_short | Chronic Administration of 5-HT1A Receptor Agonist Relieves Depression and Depression-Induced Hypoalgesia |
| title_sort | chronic administration of 5 ht1a receptor agonist relieves depression and depression induced hypoalgesia |
| url | http://dx.doi.org/10.1155/2014/405736 |
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