Erythrocyte-derived extracellular vesicles transcytose across the blood-brain barrier to induce Parkinson’s disease-like neurodegeneration

Erythrocyte-derived extracellular vesicles transcytose across the blood-brain barrier to induce Parkinson’s disease-like neurodegeneration

Abstract Parkinson’s disease (PD) is a neurodegenerative illness characterized by motor and non-motor features. Hallmarks of the disease include an extensive loss of dopaminergic neurons in the substantia nigra pars compacta, evidence of neuroinflammation, and the accumulation of misfolded proteins...

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Bibliographic Details
Main Authors: Hélèna L. Denis, Aurélie de Rus Jacquet, Melanie Alpaugh, Michel Panisset, Roger A Barker, Éric Boilard, Francesca Cicchetti
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Fluids and Barriers of the CNS
Subjects:
Parkinson’s disease
Erythrocytes
Extracellular vesicles
Blood brain barrier
3D model
Online Access:https://doi.org/10.1186/s12987-025-00646-9
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https://doi.org/10.1186/s12987-025-00646-9

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