Unearthing the burden of melioidosis in North India – an emerging threat in a non-endemic region
Burkholderia pseudomallei (B. pseudomallei) is the causative agent of the high-mortality disease called melioidosis. It is a severe infection that can be misdiagnosed due to variable presentation and low awareness among clinicians of the disease. It is endemic in India and well-described in southern...
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Elsevier
2025-01-01
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| Series: | Current Research in Microbial Sciences |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666517425000069 |
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| author | Shweta Raina Disha Gautam Rohit Kumar Kavita Sisodia Chiranjay Mukhopadhyay Harpreet Kaur Mohammed Ashiq Rushika Saksena |
| author_facet | Shweta Raina Disha Gautam Rohit Kumar Kavita Sisodia Chiranjay Mukhopadhyay Harpreet Kaur Mohammed Ashiq Rushika Saksena |
| author_sort | Shweta Raina |
| collection | DOAJ |
| description | Burkholderia pseudomallei (B. pseudomallei) is the causative agent of the high-mortality disease called melioidosis. It is a severe infection that can be misdiagnosed due to variable presentation and low awareness among clinicians of the disease. It is endemic in India and well-described in southern and eastern coastal states. In the last decade, sporadic cases of melioidosis have been diagnosed in North Indian states, predominantly Rajasthan and Gujarat. The reported cases highlight the many risk factors for infection in this region that was not previously recognised as being endemic for melioidosis, including high prevalence of diabetes mellitus, alcoholism, and large rural population engaged in paddy cultivation. Climate change results in frequent flooding and waterlogging in urban areas, leading to exposure of soil harbouring B. pseudomallei, thus a contributing factor to the rise in cases in cities. As North India has not previously been considered an endemic region for melioidosis, wider awareness amongst clinicians and laboratorians is essential for early identification of symptoms, testing for B. pseudomallei in microbiology laboratories, and timely management of the disease to save lives lost to misdiagnosis. The present article describes various aspects of melioidosis in North India including diverse clinical manifestations, risk factors, and possible reasons for misdiagnosis and underreporting. |
| format | Article |
| id | doaj-art-f56ca632a4f24cfaa739cfe1eb938965 |
| institution | Kabale University |
| issn | 2666-5174 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Microbial Sciences |
| spelling | doaj-art-f56ca632a4f24cfaa739cfe1eb9389652025-01-24T04:45:45ZengElsevierCurrent Research in Microbial Sciences2666-51742025-01-018100344Unearthing the burden of melioidosis in North India – an emerging threat in a non-endemic regionShweta Raina0Disha Gautam1Rohit Kumar2Kavita Sisodia3Chiranjay Mukhopadhyay4Harpreet Kaur5Mohammed Ashiq6Rushika Saksena7Department of Microbiology, Vardhman Mahavir medical college and Safdarjung hospital, New Delhi, IndiaDepartment of Microbiology, Vardhman Mahavir medical college and Safdarjung hospital, New Delhi, IndiaDepartment of Pulmonary, Critical Care Medicine and Sleep Medicine, Vardhman Mahavir medical college and Safdarjung hospital, New Delhi, IndiaDepartment of Microbiology, Vardhman Mahavir medical college and Safdarjung hospital, New Delhi, IndiaDepartment of Microbiology, Kasturba Medical College, Manipal, IndiaEpidemiology and Communicable Diseases, Indian Council of Medical Research, IndiaDepartment of Microbiology, Kasturba Medical College, Manipal, IndiaDepartment of Microbiology, Vardhman Mahavir medical college and Safdarjung hospital, New Delhi, India; Corresponding author at: Department of Microbiology, Vardhman Mahavir medical college and Safdarjung hospital, New Delhi.Burkholderia pseudomallei (B. pseudomallei) is the causative agent of the high-mortality disease called melioidosis. It is a severe infection that can be misdiagnosed due to variable presentation and low awareness among clinicians of the disease. It is endemic in India and well-described in southern and eastern coastal states. In the last decade, sporadic cases of melioidosis have been diagnosed in North Indian states, predominantly Rajasthan and Gujarat. The reported cases highlight the many risk factors for infection in this region that was not previously recognised as being endemic for melioidosis, including high prevalence of diabetes mellitus, alcoholism, and large rural population engaged in paddy cultivation. Climate change results in frequent flooding and waterlogging in urban areas, leading to exposure of soil harbouring B. pseudomallei, thus a contributing factor to the rise in cases in cities. As North India has not previously been considered an endemic region for melioidosis, wider awareness amongst clinicians and laboratorians is essential for early identification of symptoms, testing for B. pseudomallei in microbiology laboratories, and timely management of the disease to save lives lost to misdiagnosis. The present article describes various aspects of melioidosis in North India including diverse clinical manifestations, risk factors, and possible reasons for misdiagnosis and underreporting.http://www.sciencedirect.com/science/article/pii/S2666517425000069MelioidosisBurkholderia pseudomalleiClinical manifestationsNon-endemic areasNorth India |
| spellingShingle | Shweta Raina Disha Gautam Rohit Kumar Kavita Sisodia Chiranjay Mukhopadhyay Harpreet Kaur Mohammed Ashiq Rushika Saksena Unearthing the burden of melioidosis in North India – an emerging threat in a non-endemic region Current Research in Microbial Sciences Melioidosis Burkholderia pseudomallei Clinical manifestations Non-endemic areas North India |
| title | Unearthing the burden of melioidosis in North India – an emerging threat in a non-endemic region |
| title_full | Unearthing the burden of melioidosis in North India – an emerging threat in a non-endemic region |
| title_fullStr | Unearthing the burden of melioidosis in North India – an emerging threat in a non-endemic region |
| title_full_unstemmed | Unearthing the burden of melioidosis in North India – an emerging threat in a non-endemic region |
| title_short | Unearthing the burden of melioidosis in North India – an emerging threat in a non-endemic region |
| title_sort | unearthing the burden of melioidosis in north india an emerging threat in a non endemic region |
| topic | Melioidosis Burkholderia pseudomallei Clinical manifestations Non-endemic areas North India |
| url | http://www.sciencedirect.com/science/article/pii/S2666517425000069 |
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