Apoptotic cell-derived extracellular vesicles-MTA1 confer radioresistance in cervical cancer by inducing cellular dormancy

Apoptotic cell-derived extracellular vesicles-MTA1 confer radioresistance in cervical cancer by inducing cellular dormancy

Abstract Background Radioresistance presents a major challenge in the treatment of cervical cancer (CC). Apoptotic tumor cells can create an “onco-regenerative niche,” contributing to radioresistance. However, the intercellular signaling mechanisms mediating the transfer of radioresistance from apop...

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Main Authors: Yuan-Run Deng, Qiao-Zhi Wu, Wan Zhang, Hui-Ping Jiang, Cai-Qiu Xu, Shao-Cheng Chen, Jing Fan, Sui-Qun Guo, Xiao-Jing Chen
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Journal of Translational Medicine
Subjects:
Cervical cancer
Apoptotic tumor cell-derived extracellular vesicles (apoEVs)
MTA1
Tumor dormancy
Radioresistance
Online Access:https://doi.org/10.1186/s12967-025-06350-4
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https://doi.org/10.1186/s12967-025-06350-4

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