The Proapoptotic Effect of MB-653 Is Associated with the Modulation of Metastasis and Invasiveness-Related Signalling Pathways in Human Colorectal Cancer Cells

The Proapoptotic Effect of MB-653 Is Associated with the Modulation of Metastasis and Invasiveness-Related Signalling Pathways in Human Colorectal Cancer Cells

Colorectal cancer is one of the most common cancers worldwide and has a high mortality rate. In this study, we investigated the cytotoxic, proapoptotic, and anti-invasive effects of the synthetic indole phytoalexin MB-653. The antiproliferative effect was determined using an MTT assay, showing IC<...

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Bibliographic Details
Main Authors: Libor Sokoli, Peter Takáč, Mariana Budovská, Radka Michalková, Martin Kello, Natália Nosálová, Ľudmila Balážová, Šimon Salanci, Ján Mojžiš
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Biomolecules
Subjects:
indole phytoalexins
colorectal cancer
apoptosis
metastasis
EMT
Online Access:https://www.mdpi.com/2218-273X/15/1/72
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