Mutant Fam20c knock-in mice recapitulate both lethal and non-lethal human Raine Syndrome

Mutant Fam20c knock-in mice recapitulate both lethal and non-lethal human Raine Syndrome

Abstract Background Inactivation or mutations of FAM20C causes human Raine Syndrome, which manifests as lethal osteosclerosis bone dysplasia or non-lethal hypophosphatemia rickets. However, it is only hypophosphatemia rickets that was reported in the mice with Fam20c deletion or mutations. To furthe...

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Main Authors: Mengnan Chen, Dongmei Sun, Siu-Pok Yee, Zhaoyang Yuan, Li Lin, Bing Cui, Yi Wang, Chao Liu, Peihong Liu
Format: Article
Language:English
Published: BMC 2025-01-01
Series:BMC Molecular and Cell Biology
Subjects:
FAM20C
Raine syndrome
Osteosclerosis
Hypophosphataemic rickets
Biomineralization
Online Access:https://doi.org/10.1186/s12860-024-00526-4
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https://doi.org/10.1186/s12860-024-00526-4

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