Harmine alleviates LPS-induced acute lung injury by inhibiting CSF3-mediated MAPK/NF-κB signaling pathway

Harmine alleviates LPS-induced acute lung injury by inhibiting CSF3-mediated MAPK/NF-κB signaling pathway

Abstract Background Acute lung injury (ALI) is a life-threatening inflammatory lung disease that lacks safe and effective treatment strategies. Harmine, an alkaloid derived from Peganum harmala L plants, exhibits anti-inflammatory activity. However, the protective effect of harmine against ALI and i...

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Bibliographic Details
Main Authors: Yihui Zhai, Kejie Chen, Zichuang Xu, Xiaojian Chen, Jiaying Tong, Yeying He, Chaoyue Chen, Meiqing Ding, Guang Liang, Xiaohui Zheng
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Respiratory Research
Subjects:
Acute lung injury
MAPK/NF-κB signaling pathway
Harmine
Inflammatory
Granulocyte Colony-Stimulating factor (CSF3)
Online Access:https://doi.org/10.1186/s12931-025-03196-8
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