[18F]FDG PET metabolic correlates of cerebrospinal fluid TAR DNA-binding protein 43 in prodromal Alzheimer's disease

[18F]FDG PET metabolic correlates of cerebrospinal fluid TAR DNA-binding protein 43 in prodromal Alzheimer's disease

Introduction: Limbic-predominant age-related TDP-43 encephalopathy neuropathological changes (LATE-NC) are characterized by phosphorylated TDP-43 aggregates in limbic regions, often co-occurring with Alzheimer's disease (AD) pathology, amplifying clinical and neuroimaging alterations. In vivo b...

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Main Authors: Virginia Pelagotti, Domenico Plantone, Francesca D’Amico, Stefano Raffa, Pietro Mattioli, Beatrice Orso, Mattia Losa, Carlo Manco, Delia Righi, Dario Arnaldi, Antonio Uccelli, Andrea Chincarini, Gianmario Sambuceti, Silvia Morbelli, Nicola De Stefano, Federico Massa, Matteo Pardini
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
LATE
FDG-PET
TDP-43
Online Access:http://www.sciencedirect.com/science/article/pii/S096999612500230X
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