Genome-Wide Association Studies of Hypertension: Light at the End of the Tunnel
Despite its significant genetic component, the study of hypertension by genome-wide association presents more challenges than other common complex diseases. Its high prevalence, heterogeneity, and somewhat unclear definition are the challenges that need to be overcome on one hand. On the other hand,...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.4061/2010/509581 |
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| _version_ | 1832563191682433024 |
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| author | Claire E. Hastie Sandosh Padmanabhan Anna F. Dominiczak |
| author_facet | Claire E. Hastie Sandosh Padmanabhan Anna F. Dominiczak |
| author_sort | Claire E. Hastie |
| collection | DOAJ |
| description | Despite its significant genetic component, the study of hypertension by genome-wide
association presents more challenges than other common complex diseases. Its high
prevalence, heterogeneity, and somewhat unclear definition are the challenges that need
to be overcome on one hand. On the other hand, there are issues of small effect sizes and
pleiotropism that are not specific to hypertension alone but nonetheless magnify the
problems of genetic dissection when coupled with phenotypic misclassification. We
discuss issues of study design and summarise published genome-wide association studies
(GWASs) of hypertension and blood pressure. With careful study design and analysis
success is possible, as demonstrated by the recent large-scale studies. Following these, there
is still further scope to advance the field through high fidelity phenotyping and deep
sequencing. |
| format | Article |
| id | doaj-art-f4666ea77e8f4bcfa489760e6419a8ae |
| institution | Kabale University |
| issn | 2090-0392 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-f4666ea77e8f4bcfa489760e6419a8ae2025-02-03T01:20:53ZengWileyInternational Journal of Hypertension2090-03922010-01-01201010.4061/2010/509581509581Genome-Wide Association Studies of Hypertension: Light at the End of the TunnelClaire E. Hastie0Sandosh Padmanabhan1Anna F. Dominiczak2British Heart Foundation Cardiovascular Research Centre, University of Glasgow, 126 University Place, Glasgow G12 8TA, UKBritish Heart Foundation Cardiovascular Research Centre, University of Glasgow, 126 University Place, Glasgow G12 8TA, UKBritish Heart Foundation Cardiovascular Research Centre, University of Glasgow, 126 University Place, Glasgow G12 8TA, UKDespite its significant genetic component, the study of hypertension by genome-wide association presents more challenges than other common complex diseases. Its high prevalence, heterogeneity, and somewhat unclear definition are the challenges that need to be overcome on one hand. On the other hand, there are issues of small effect sizes and pleiotropism that are not specific to hypertension alone but nonetheless magnify the problems of genetic dissection when coupled with phenotypic misclassification. We discuss issues of study design and summarise published genome-wide association studies (GWASs) of hypertension and blood pressure. With careful study design and analysis success is possible, as demonstrated by the recent large-scale studies. Following these, there is still further scope to advance the field through high fidelity phenotyping and deep sequencing.http://dx.doi.org/10.4061/2010/509581 |
| spellingShingle | Claire E. Hastie Sandosh Padmanabhan Anna F. Dominiczak Genome-Wide Association Studies of Hypertension: Light at the End of the Tunnel International Journal of Hypertension |
| title | Genome-Wide Association Studies of Hypertension: Light at the End of the Tunnel |
| title_full | Genome-Wide Association Studies of Hypertension: Light at the End of the Tunnel |
| title_fullStr | Genome-Wide Association Studies of Hypertension: Light at the End of the Tunnel |
| title_full_unstemmed | Genome-Wide Association Studies of Hypertension: Light at the End of the Tunnel |
| title_short | Genome-Wide Association Studies of Hypertension: Light at the End of the Tunnel |
| title_sort | genome wide association studies of hypertension light at the end of the tunnel |
| url | http://dx.doi.org/10.4061/2010/509581 |
| work_keys_str_mv | AT claireehastie genomewideassociationstudiesofhypertensionlightattheendofthetunnel AT sandoshpadmanabhan genomewideassociationstudiesofhypertensionlightattheendofthetunnel AT annafdominiczak genomewideassociationstudiesofhypertensionlightattheendofthetunnel |