Gut microbiota and HMGB1/NLRP3/GSDMD inflammasome-dependent pyroptosis: mechanisms by physcion ameliorates alcoholic liver fibrosis

Gut microbiota and HMGB1/NLRP3/GSDMD inflammasome-dependent pyroptosis: mechanisms by physcion ameliorates alcoholic liver fibrosis

Alcoholic liver fibrosis (ALF) developed from long-term excessive alcohol consumption, which causes inflammatory reactions, lipid accumulation and cirrhosis. An imbalance in gut microbiota is a crucial driving factor for liver fibrosis through the gut-liver axis. This study aimed to explore the effe...

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Bibliographic Details
Main Authors: Ting Bai, Hao-Lin Guo, Fei Wang, Yan-Yu Kang, Hao-Tian Zhang, Lu Dong, Yong Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Pharmacology
Subjects:
alcoholic liver fibrosis
physcion
gut microbiota
HMGB1
NLRP3
cysteinyl aspartate specific proteinase-1 (Caspase-1)
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1532590/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1532590/full

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