Epigenome-wide association study for dilated cardiomyopathy in left ventricular heart tissue identifies putative gene sets associated with cardiac pathology and early indicators of cardiac risk

Epigenome-wide association study for dilated cardiomyopathy in left ventricular heart tissue identifies putative gene sets associated with cardiac pathology and early indicators of cardiac risk

Abstract Background Methylation changes linked to dilated cardiomyopathy (DCM) affect cardiac gene expression. We investigate DCM mechanisms regulated by CpG methylation using multi-omics and causal analyses in the largest cohort of left ventricular tissues available. Methods We mapped DNA methylati...

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Main Authors: Konstanze Tan, Darwin Tay, Wilson Tan, Hong Kiat Ng, Eleanor Wong, Michael P. Morley, Gurpreet K. Singhera, Chang Jie Mick Lee, Pritesh R. Jain, Fei Li Tai, Paul J. Hanson, Thomas P. Cappola, Kenneth B. Margulies, Roger Foo, Marie Loh
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Clinical Epigenetics
Online Access:https://doi.org/10.1186/s13148-025-01854-8
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https://doi.org/10.1186/s13148-025-01854-8

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