Metabolomics- and proteomics-based multi-omics integration reveals early metabolite alterations in sepsis-associated acute kidney injury

Metabolomics- and proteomics-based multi-omics integration reveals early metabolite alterations in sepsis-associated acute kidney injury

Abstract Background Sepsis-associated acute kidney injury (SA-AKI) is a frequent complication in patients with sepsis and is associated with high mortality. Therefore, early recognition of SA-AKI is essential for administering supportive treatment and preventing further damage. This study aimed to i...

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Main Authors: Pengfei Huang, Yanqi Liu, Yue Li, Yu Xin, Chuanchuan Nan, Yinghao Luo, Yating Feng, Nana Jin, Yahui Peng, Dawei Wang, Yang Zhou, Feiyu Luan, Xinran Wang, Xibo Wang, Hongxu Li, Yuxin Zhou, Weiting Zhang, Yuhan Liu, Mengyao Yuan, Yuxin Zhang, Yuchen Song, Yu Xiao, Lifeng Shen, Kaijiang Yu, Mingyan Zhao, Lixin Cheng, Changsong Wang
Format: Article
Language:English
Published: BMC 2025-02-01
Series:BMC Medicine
Subjects:
Sepsis-associated acute kidney injury
Sepsis
Multi-omics analysis
Metabolome
Proteome
Diagnostic biomarkers
Online Access:https://doi.org/10.1186/s12916-025-03920-7
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