Long-term hypoxic atmosphere enhances the stemness, immunoregulatory functions, and therapeutic application of human umbilical cord mesenchymal stem cells

Long-term hypoxic atmosphere enhances the stemness, immunoregulatory functions, and therapeutic application of human umbilical cord mesenchymal stem cells

Aims: Mesenchymal stem cells (MSCs) are usually cultured in a normoxic atmosphere (21%) in vitro, while the oxygen concentrations in human tissues and organs are 1% to 10% when the cells are transplanted in vivo. However, the impact of hypoxia on MSCs has not been deeply studied, especially its tra...

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Bibliographic Details
Main Authors: Qi-Ming Huang, You-Qiong Zhuo, Zhong-Xin Duan, Yin-lin Long, Jia-Nan Wang, Zhou-hang Zhang, Shao-Yong Fan, Yong-Ming Huang, Ke-Yu Deng, Hong-Bo Xin
Format: Article
Language:English
Published: The British Editorial Society of Bone & Joint Surgery 2024-12-01
Series:Bone & Joint Research
Subjects:
mesenchymal stem cells
hypoxia
osteoarthritis
mesenchymal stem cells (mscs)
chondrocytes
mice model
transplantations
mmp-13
apoptosis
osteoarthritis (oa)
cartilage damage
swelling
Online Access:https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.1312.BJR-2024-0136.R2
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