A thermodynamic bottleneck in the TCA cycle contributes to acetate overflow in Staphylococcus aureus

A thermodynamic bottleneck in the TCA cycle contributes to acetate overflow in Staphylococcus aureus

ABSTRACT During aerobic growth, S. aureus relies on acetate overflow metabolism, a process where glucose is incompletely oxidized to acetate, for its bioenergetic needs. Acetate is not immediately captured as a carbon source and is excreted as waste by cells. The underlying factors governing acetate...

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Main Authors: Nabia Shahreen, Jongsam Ahn, Adil Alsiyabi, Niaz Bahar Chowdhury, Dhananjay Shinde, Sujata S. Chaudhari, Kenneth W. Bayles, Vinai C. Thomas, Rajib Saha
Format: Article
Language:English
Published: American Society for Microbiology 2025-01-01
Series:mSphere
Subjects:
overflow metabolism
redox imbalance
thermodynamic bottleneck
membrane crowding
acetate overflow
Online Access:https://journals.asm.org/doi/10.1128/msphere.00883-24
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https://journals.asm.org/doi/10.1128/msphere.00883-24

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