Donor and Recipient Polygenic Risk Scores Influence Kidney Transplant Function

Donor and Recipient Polygenic Risk Scores Influence Kidney Transplant Function

Kidney transplant outcomes are influenced by donor and recipient age, sex, HLA mismatch, donor type, anti-rejection medication adherence and disease recurrence, but variability in transplant outcomes remains unexplained. We hypothesise that donor and recipient polygenic burden for traits related to...

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Bibliographic Details
Main Authors: Kane E. Collins, Edmund Gilbert, Vincent Mauduit, Katherine A. Benson, Elhussein A. E. Elhassan, Conall O’Seaghdha, Claire Hill, Amy Jayne McKnight, Alexander P. Maxwell, Peter J. van der Most, Martin H. de Borst, Weihua Guan, Pamala A. Jacobson, Ajay K. Israni, Brendan J. Keating, Graham M. Lord, Salla Markkinen, Ilkka Helanterä, Kati Hyvärinen, Jukka Partanen, Stephen F. Madden, Matthew B. Lanktree, Sophie Limou, Gianpiero L. Cavalleri, Peter J. Conlon
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Transplant International
Subjects:
polygenic risk scores
eGFR
graft survival
graft function
multivariable models
Online Access:https://www.frontierspartnerships.org/articles/10.3389/ti.2025.14171/full
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