Cell-Based Therapy for Cerebral Palsy: A Puzzle in Progress
Cell-based therapy has shown promising outcomes in the treatment of cerebral palsy (CP). However, there is noconsensus on a standard therapeutic protocol regarding the source of cells, optimal cell dose, timing and frequencyof cell injections, route of administration, or the use of combination thera...
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| Format: | Article |
| Language: | English |
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Royan Institute (ACECR), Tehran
2024-09-01
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| Series: | Cell Journal |
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| Online Access: | https://www.celljournal.org/article_715940_427179cef4e370f585aea4aee2e405bd.pdf |
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| _version_ | 1832595295810093056 |
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| author | Masoumeh Nouri Morteza Zarrabi Safdar Masoumi Elaheh Khodadoust Anahita Majmae Man Amanat Mahmoud Reza Ashrafi Massoud Vosough |
| author_facet | Masoumeh Nouri Morteza Zarrabi Safdar Masoumi Elaheh Khodadoust Anahita Majmae Man Amanat Mahmoud Reza Ashrafi Massoud Vosough |
| author_sort | Masoumeh Nouri |
| collection | DOAJ |
| description | Cell-based therapy has shown promising outcomes in the treatment of cerebral palsy (CP). However, there is noconsensus on a standard therapeutic protocol regarding the source of cells, optimal cell dose, timing and frequencyof cell injections, route of administration, or the use of combination therapy. This lack of consensus necessitates acomprehensive investigation to clarify these crucial yet undefined factors in cell-based therapy for CP patients. In thiscommentary, we discuss and compare the trends in Gross Motor Function Measure-66 following intrathecal injectionof umbilical cord blood mononuclear cells (UCB-MNCs) and umbilical cord tissue mesenchymal stromal cells (UCTMSCs)in children with CP. Our study revealed that MNC injections led to earlier improvements in gross motor function,whereas MSC applications resulted in more sustainable changes. These findings provide key insights into the efficacyof different cell types, which will be beneficial for future studies and for refining cell-based therapy protocols for CPtreatment. |
| format | Article |
| id | doaj-art-f42e73b2bf294d6b84e9aaac9cfa325d |
| institution | Kabale University |
| issn | 2228-5806 2228-5814 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Royan Institute (ACECR), Tehran |
| record_format | Article |
| series | Cell Journal |
| spelling | doaj-art-f42e73b2bf294d6b84e9aaac9cfa325d2025-01-19T09:34:58ZengRoyan Institute (ACECR), TehranCell Journal2228-58062228-58142024-09-0126956957410.22074/cellj.2024.2032098.1600715940Cell-Based Therapy for Cerebral Palsy: A Puzzle in ProgressMasoumeh Nouri0Morteza Zarrabi1Safdar Masoumi2Elaheh Khodadoust3Anahita Majmae4Man Amanat5Mahmoud Reza Ashrafi6Massoud Vosough7R&D Department, Royan Stem Cell Technology Company, Tehran, IranDepartment of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, IranEndocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IranR&D Department, Royan Stem Cell Technology Company, Tehran, IranChildren’s Medical Center, Pediatrics Center of Excellence, Tehran, IranDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USAPediatric Neurology Division, Children’s Medical Center, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, IranDepartment of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, IranCell-based therapy has shown promising outcomes in the treatment of cerebral palsy (CP). However, there is noconsensus on a standard therapeutic protocol regarding the source of cells, optimal cell dose, timing and frequencyof cell injections, route of administration, or the use of combination therapy. This lack of consensus necessitates acomprehensive investigation to clarify these crucial yet undefined factors in cell-based therapy for CP patients. In thiscommentary, we discuss and compare the trends in Gross Motor Function Measure-66 following intrathecal injectionof umbilical cord blood mononuclear cells (UCB-MNCs) and umbilical cord tissue mesenchymal stromal cells (UCTMSCs)in children with CP. Our study revealed that MNC injections led to earlier improvements in gross motor function,whereas MSC applications resulted in more sustainable changes. These findings provide key insights into the efficacyof different cell types, which will be beneficial for future studies and for refining cell-based therapy protocols for CPtreatment.https://www.celljournal.org/article_715940_427179cef4e370f585aea4aee2e405bd.pdfcerebral palsymononuclear cellsmesenchymal stromal cellsgross motor function measure-66 |
| spellingShingle | Masoumeh Nouri Morteza Zarrabi Safdar Masoumi Elaheh Khodadoust Anahita Majmae Man Amanat Mahmoud Reza Ashrafi Massoud Vosough Cell-Based Therapy for Cerebral Palsy: A Puzzle in Progress Cell Journal cerebral palsy mononuclear cells mesenchymal stromal cells gross motor function measure-66 |
| title | Cell-Based Therapy for Cerebral Palsy: A Puzzle in Progress |
| title_full | Cell-Based Therapy for Cerebral Palsy: A Puzzle in Progress |
| title_fullStr | Cell-Based Therapy for Cerebral Palsy: A Puzzle in Progress |
| title_full_unstemmed | Cell-Based Therapy for Cerebral Palsy: A Puzzle in Progress |
| title_short | Cell-Based Therapy for Cerebral Palsy: A Puzzle in Progress |
| title_sort | cell based therapy for cerebral palsy a puzzle in progress |
| topic | cerebral palsy mononuclear cells mesenchymal stromal cells gross motor function measure-66 |
| url | https://www.celljournal.org/article_715940_427179cef4e370f585aea4aee2e405bd.pdf |
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