Investigation of GPR137C as a promising novel marker for the progression of prostate cancer through G4 screen and bioinformatics analyses

Investigation of GPR137C as a promising novel marker for the progression of prostate cancer through G4 screen and bioinformatics analyses

IntroductionProstate cancer (PCa) remains the fifth leading cause of male cancer mortality, necessitating novel biomarkers and therapeutic targets.MethodsThrough BG4 ChIP-seq profiling in PCa cells, we identified promoter G-quadruplex (G4) structures in prognosis-associated genes, with GPR137C exhib...

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Bibliographic Details
Main Authors: Yue Hou, Haowen Lu, Saisai Chen, Likai Mao, Xuan Huang, Feng Xu, Chuanjun Shu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
G-quadruplex
prostate cancer
GPR137C
GPCRs de-orphanization
drugs
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1576835/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1576835/full

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