Extracellular matrix turnover in severe COVID-19 is reduced by corticosteroids

Extracellular matrix turnover in severe COVID-19 is reduced by corticosteroids

Abstract Background Severe and critical COVID-19 is characterized by pulmonary viral infection with SARS-CoV-2 resulting in local and systemic inflammation. Dexamethasone (DEX) has been shown to improve outcomes in critically ill patients; however, its effect on tissue remodeling, particularly colla...

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Main Authors: Janesh Pillay, Antine W. Flikweert, Matijs van Meurs, Marco J. Grootenboers, Simone van der Sar-van der Brugge, Peter H. J. van der Voort, Morten A. Karsdal, Jannie M. B. Sand, Diana J. Leeming, Janette K. Burgess, Jill Moser
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Respiratory Research
Subjects:
COVID-19
ARDS
Extracellular matrix
Neo-epitopes
Corticosteroids
Online Access:https://doi.org/10.1186/s12931-025-03098-9
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https://doi.org/10.1186/s12931-025-03098-9

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