SNAP25-dependent membrane trafficking of the Kv1.5 channel regulates the onset of atrial fibrillation

SNAP25-dependent membrane trafficking of the Kv1.5 channel regulates the onset of atrial fibrillation

Abstract Synaptosomal-associated protein 25 kDa (SNAP25) is essential for vesicular trafficking and protein docking at presynaptic membranes in the nervous system, yet its role in the heart remains poorly understood. Here, we show an unrecognized function of SNAP25, which is selectively expressed in...

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Main Authors: Xuling Su, Beihua Shao, Zhiwen Chen, Hongcheng Gu, Ke Xiong, Guanghua Wang, Qicheng Zou, Yuting Cao, Caihong Zhang, Hongtao Xu, Yixin Yuan, Xuxia Zhao, Yi Liu, Yunli Shen, Duanyang Xie, Yi-Han Chen
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59096-4
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https://doi.org/10.1038/s41467-025-59096-4

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