Evaluation of targeting accuracy of cone beam CT guided histotripsy in an in vivo porcine model
Purpose The application of histotripsy, an emerging noninvasive, non-ionizing, and non-thermal tumor treatment, is currently limited by the inherent limitations of diagnostic ultrasound as the sole targeting modality. This study evaluates the feasibility and accuracy of cone beam computed tomography...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2025-12-01
|
| Series: | International Journal of Hyperthermia |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/02656736.2025.2455138 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832591203005104128 |
|---|---|
| author | Martin G. Wagner Grace M. Minesinger Katrina L. Falk Ayca Z. Kutlu Meridith A. Kisting Michael A. Speidel Timothy J. Ziemlewicz J. Louis Hinshaw John F. Swietlik Fred T. Lee Paul F. Laeseke |
| author_facet | Martin G. Wagner Grace M. Minesinger Katrina L. Falk Ayca Z. Kutlu Meridith A. Kisting Michael A. Speidel Timothy J. Ziemlewicz J. Louis Hinshaw John F. Swietlik Fred T. Lee Paul F. Laeseke |
| author_sort | Martin G. Wagner |
| collection | DOAJ |
| description | Purpose The application of histotripsy, an emerging noninvasive, non-ionizing, and non-thermal tumor treatment, is currently limited by the inherent limitations of diagnostic ultrasound as the sole targeting modality. This study evaluates the feasibility and accuracy of cone beam computed tomography (CBCT) guidance for histotripsy treatments in an in vivo porcine model.Materials and methods Histotripsy treatments were performed in the liver of seven healthy swine under the guidance of a C-arm CBCT system that was calibrated to the robotic arm of the histotripsy system. For each treatment, pseudotumors (small histotripsy treatments of 15 mm) were created using conventional US guidance to serve as targets for subsequent CBCT guided treatments. A pretreatment CBCT with intravenous contrast was acquired for each swine and the center of the pseudotumor was selected as the target. The robotic arm automatically aligned the transducer to the selected target location. Ultrasound based aberration offset correction was performed when possible, and a 25 mm diameter treatment was performed. A post-treatment CBCT with intravenous contrast was then acquired to evaluate coverage, treatment size, and distance between the pseudotumor target and actual treatment zone center.Results Treatments were technically successful and pseudotumors were completely covered in all seven treatments (7/7). The average treatment diameter was 39.3 ± 4.2 mm. The center-to-center distance between pseudotumor and actual treatments was 3.8 ± 1.3 mm.Conclusion CBCT provides accurate targeting for histotripsy treatment in vivo. While future work is required to assess safety and efficacy in the presence of obstructions, the proposed approach could supplement ultrasound imaging for targeting. |
| format | Article |
| id | doaj-art-f3b027d1dae0472981673cffa7bd675f |
| institution | Kabale University |
| issn | 0265-6736 1464-5157 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Hyperthermia |
| spelling | doaj-art-f3b027d1dae0472981673cffa7bd675f2025-01-23T00:55:10ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572025-12-0142110.1080/02656736.2025.2455138Evaluation of targeting accuracy of cone beam CT guided histotripsy in an in vivo porcine modelMartin G. Wagner0Grace M. Minesinger1Katrina L. Falk2Ayca Z. Kutlu3Meridith A. Kisting4Michael A. Speidel5Timothy J. Ziemlewicz6J. Louis Hinshaw7John F. Swietlik8Fred T. Lee9Paul F. Laeseke10Department of Radiology, University of Wisconsin, Madison, WI, USADepartment of Medical Physics, University of Wisconsin, Madison, WI, USADepartment of Radiology, University of Wisconsin, Madison, WI, USADepartment of Radiology, University of Wisconsin, Madison, WI, USADepartment of Radiology, University of Wisconsin, Madison, WI, USADepartment of Medical Physics, University of Wisconsin, Madison, WI, USADepartment of Radiology, University of Wisconsin, Madison, WI, USADepartment of Radiology, University of Wisconsin, Madison, WI, USADepartment of Radiology, University of Wisconsin, Madison, WI, USADepartment of Radiology, University of Wisconsin, Madison, WI, USADepartment of Radiology, University of Wisconsin, Madison, WI, USAPurpose The application of histotripsy, an emerging noninvasive, non-ionizing, and non-thermal tumor treatment, is currently limited by the inherent limitations of diagnostic ultrasound as the sole targeting modality. This study evaluates the feasibility and accuracy of cone beam computed tomography (CBCT) guidance for histotripsy treatments in an in vivo porcine model.Materials and methods Histotripsy treatments were performed in the liver of seven healthy swine under the guidance of a C-arm CBCT system that was calibrated to the robotic arm of the histotripsy system. For each treatment, pseudotumors (small histotripsy treatments of 15 mm) were created using conventional US guidance to serve as targets for subsequent CBCT guided treatments. A pretreatment CBCT with intravenous contrast was acquired for each swine and the center of the pseudotumor was selected as the target. The robotic arm automatically aligned the transducer to the selected target location. Ultrasound based aberration offset correction was performed when possible, and a 25 mm diameter treatment was performed. A post-treatment CBCT with intravenous contrast was then acquired to evaluate coverage, treatment size, and distance between the pseudotumor target and actual treatment zone center.Results Treatments were technically successful and pseudotumors were completely covered in all seven treatments (7/7). The average treatment diameter was 39.3 ± 4.2 mm. The center-to-center distance between pseudotumor and actual treatments was 3.8 ± 1.3 mm.Conclusion CBCT provides accurate targeting for histotripsy treatment in vivo. While future work is required to assess safety and efficacy in the presence of obstructions, the proposed approach could supplement ultrasound imaging for targeting.https://www.tandfonline.com/doi/10.1080/02656736.2025.2455138Histotripsycone beam CTimage-to-robot registrationhand-eye calibrationfocused ultrasound |
| spellingShingle | Martin G. Wagner Grace M. Minesinger Katrina L. Falk Ayca Z. Kutlu Meridith A. Kisting Michael A. Speidel Timothy J. Ziemlewicz J. Louis Hinshaw John F. Swietlik Fred T. Lee Paul F. Laeseke Evaluation of targeting accuracy of cone beam CT guided histotripsy in an in vivo porcine model International Journal of Hyperthermia Histotripsy cone beam CT image-to-robot registration hand-eye calibration focused ultrasound |
| title | Evaluation of targeting accuracy of cone beam CT guided histotripsy in an in vivo porcine model |
| title_full | Evaluation of targeting accuracy of cone beam CT guided histotripsy in an in vivo porcine model |
| title_fullStr | Evaluation of targeting accuracy of cone beam CT guided histotripsy in an in vivo porcine model |
| title_full_unstemmed | Evaluation of targeting accuracy of cone beam CT guided histotripsy in an in vivo porcine model |
| title_short | Evaluation of targeting accuracy of cone beam CT guided histotripsy in an in vivo porcine model |
| title_sort | evaluation of targeting accuracy of cone beam ct guided histotripsy in an in vivo porcine model |
| topic | Histotripsy cone beam CT image-to-robot registration hand-eye calibration focused ultrasound |
| url | https://www.tandfonline.com/doi/10.1080/02656736.2025.2455138 |
| work_keys_str_mv | AT martingwagner evaluationoftargetingaccuracyofconebeamctguidedhistotripsyinaninvivoporcinemodel AT gracemminesinger evaluationoftargetingaccuracyofconebeamctguidedhistotripsyinaninvivoporcinemodel AT katrinalfalk evaluationoftargetingaccuracyofconebeamctguidedhistotripsyinaninvivoporcinemodel AT aycazkutlu evaluationoftargetingaccuracyofconebeamctguidedhistotripsyinaninvivoporcinemodel AT meridithakisting evaluationoftargetingaccuracyofconebeamctguidedhistotripsyinaninvivoporcinemodel AT michaelaspeidel evaluationoftargetingaccuracyofconebeamctguidedhistotripsyinaninvivoporcinemodel AT timothyjziemlewicz evaluationoftargetingaccuracyofconebeamctguidedhistotripsyinaninvivoporcinemodel AT jlouishinshaw evaluationoftargetingaccuracyofconebeamctguidedhistotripsyinaninvivoporcinemodel AT johnfswietlik evaluationoftargetingaccuracyofconebeamctguidedhistotripsyinaninvivoporcinemodel AT fredtlee evaluationoftargetingaccuracyofconebeamctguidedhistotripsyinaninvivoporcinemodel AT paulflaeseke evaluationoftargetingaccuracyofconebeamctguidedhistotripsyinaninvivoporcinemodel |