Activation of Wnt/β-catenin in neural progenitor cells regulates blood–brain barrier development and promotes neuroinflammation

Activation of Wnt/β-catenin in neural progenitor cells regulates blood–brain barrier development and promotes neuroinflammation

Abstract The central nervous system (CNS) requires specialized blood vessels to support neural function within specific microenvironments. During neurovascular development, endothelial Wnt/β-catenin signaling is required for BBB development within the brain parenchyma, whereas fenestrated blood vess...

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Bibliographic Details
Main Authors: Dylan J. Sebo, Irshad Ali, Audrey R. Fetsko, Aubrey A. Trimbach, Michael R. Taylor
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Blood–Brain barrier (BBB)
Endothelial cells (ECs)
Neural progenitor cells (NPCs)
Neuroinflammation
Wnt/β-catenin
Zebrafish
Online Access:https://doi.org/10.1038/s41598-025-85784-8
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https://doi.org/10.1038/s41598-025-85784-8

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