Brain tau PET-based identification and characterization of subpopulations in patients with Alzheimer’s disease using deep learning-derived saliency maps

Brain tau PET-based identification and characterization of subpopulations in patients with Alzheimer’s disease using deep learning-derived saliency maps

Abstract Background Alzheimer’s disease (AD) is a heterogeneous neurodegenerative disorder in which tau neurofibrillary tangles are a pathological hallmark closely associated with cognitive dysfunction and neurodegeneration. In this study, we used brain tau data to investigate AD heterogeneity by id...

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Main Authors: Yanxiao Li, Xiuying Wang, Qi Ge, Manuel B Graeber, Shaozhen Yan, Jian Li, Shuyu Li, Wenjian Gu, Shuo Hu, Tammie L. S. Benzinger, Jie Lu, Yun Zhou
Format: Article
Language:English
Published: SpringerOpen 2025-06-01
Series:EJNMMI Physics
Subjects:
Alzheimer’s disease
Tau PET
Heterogeneity
Deep learning
Saliency map
Cognitive
Online Access:https://doi.org/10.1186/s40658-025-00761-4
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https://doi.org/10.1186/s40658-025-00761-4

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