Mapping dynamic regulation of gene expression using single-cell transcriptomics and application to complex disease genetics
Summary: Single-cell transcriptome data can provide insights into how genetic variation influences biological processes involved in human physiology and disease. However, the identification of gene-level associations in distinct cell types faces several challenges, including the limited reference re...
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Main Authors: | Hanna Abe, Phillip Lin, Dan Zhou, Douglas M. Ruderfer, Eric R. Gamazon |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2025-04-01
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Series: | HGG Advances |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2666247724001374 |
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