Preoperative hemoglobin A1c is associated with postoperative bleeding after vitrectomy for vitreous hemorrhage in patients with diabetic retinopathy
We previously reported that a high HbA1c level 3 months before vitrectomy for vitreous hemorrhage or a large preoperative decrease in the HbA1c level over 3 months tended to increase the risk of rebleeding in diabetic retinopathy patients evaluated between 2010 and 2014. Here, we aimed to confirm th...
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The Japan Endocrine Society
2024-10-01
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| Series: | Endocrine Journal |
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| Online Access: | https://www.jstage.jst.go.jp/article/endocrj/71/10/71_EJ23-0301/_html/-char/en |
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| author | Saori Motoda Masanori Kanai Susumu Sakimoto Harutoshi Ozawa Chisaki Ishibashi Shingo Fujita Yoshiya Hosokawa Megu Y. Baden Yukari Fujita Takekazu Kimura Ayumi Tokunaga Takao Nammo Kenji Fukui Junji Kozawa Hirokazu Sakaguchi Kohji Nishida Iichiro Shimomura |
| author_facet | Saori Motoda Masanori Kanai Susumu Sakimoto Harutoshi Ozawa Chisaki Ishibashi Shingo Fujita Yoshiya Hosokawa Megu Y. Baden Yukari Fujita Takekazu Kimura Ayumi Tokunaga Takao Nammo Kenji Fukui Junji Kozawa Hirokazu Sakaguchi Kohji Nishida Iichiro Shimomura |
| author_sort | Saori Motoda |
| collection | DOAJ |
| description | We previously reported that a high HbA1c level 3 months before vitrectomy for vitreous hemorrhage or a large preoperative decrease in the HbA1c level over 3 months tended to increase the risk of rebleeding in diabetic retinopathy patients evaluated between 2010 and 2014. Here, we aimed to confirm these results with an extended study period and an increased number of operated eyes. This study included 121 diabetic patients who were admitted to Osaka University Hospital between 2010 and 2019 and who underwent vitrectomy for vitreous hemorrhage. Binomial logistic regression analysis was performed with the presence of postoperative bleeding as the outcome. The present study showed that the duration of the operation was associated with rebleeding (odds ratio = 1.02, p = 0.0016). A high HbA1c level just before vitrectomy tended to be associated with the bleeding (odds ratio = 1.27, p = 0.05), while preoperative HbA1c changes were not associated with rebleeding. The results of this study suggest that a high preoperative HbA1c level just before vitrectomy, not a decrease in HbA1c levels, in addition to the duration of the operation may increase the risk of postoperative bleeding after vitrectomy in diabetic retinopathy patients. |
| format | Article |
| id | doaj-art-f389620ab09b46bbad0bc6c149bb52a4 |
| institution | Kabale University |
| issn | 1348-4540 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | The Japan Endocrine Society |
| record_format | Article |
| series | Endocrine Journal |
| spelling | doaj-art-f389620ab09b46bbad0bc6c149bb52a42025-01-22T05:22:56ZengThe Japan Endocrine SocietyEndocrine Journal1348-45402024-10-01711096597110.1507/endocrj.EJ23-0301endocrjPreoperative hemoglobin A1c is associated with postoperative bleeding after vitrectomy for vitreous hemorrhage in patients with diabetic retinopathySaori Motoda0Masanori Kanai1Susumu Sakimoto2Harutoshi Ozawa3Chisaki Ishibashi4Shingo Fujita5Yoshiya Hosokawa6Megu Y. Baden7Yukari Fujita8Takekazu Kimura9Ayumi Tokunaga10Takao Nammo11Kenji Fukui12Junji Kozawa13Hirokazu Sakaguchi14Kohji Nishida15Iichiro Shimomura16Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita 565-0871, JapanDepartment of Ophthalmology, Graduate School of Medicine, Osaka University, Suita 565-0871, JapanDepartment of Ophthalmology, Graduate School of Medicine, Osaka University, Suita 565-0871, JapanDepartment of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita 565-0871, JapanDepartment of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita 565-0871, JapanDepartment of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita 565-0871, JapanDepartment of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita 565-0871, JapanDepartment of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita 565-0871, JapanDepartment of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita 565-0871, JapanDepartment of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita 565-0871, JapanDepartment of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita 565-0871, JapanDepartment of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita 565-0871, JapanDepartment of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita 565-0871, JapanDepartment of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita 565-0871, JapanDepartment of Ophthalmology, Graduate School of Medicine, Osaka University, Suita 565-0871, JapanDepartment of Ophthalmology, Graduate School of Medicine, Osaka University, Suita 565-0871, JapanDepartment of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita 565-0871, JapanWe previously reported that a high HbA1c level 3 months before vitrectomy for vitreous hemorrhage or a large preoperative decrease in the HbA1c level over 3 months tended to increase the risk of rebleeding in diabetic retinopathy patients evaluated between 2010 and 2014. Here, we aimed to confirm these results with an extended study period and an increased number of operated eyes. This study included 121 diabetic patients who were admitted to Osaka University Hospital between 2010 and 2019 and who underwent vitrectomy for vitreous hemorrhage. Binomial logistic regression analysis was performed with the presence of postoperative bleeding as the outcome. The present study showed that the duration of the operation was associated with rebleeding (odds ratio = 1.02, p = 0.0016). A high HbA1c level just before vitrectomy tended to be associated with the bleeding (odds ratio = 1.27, p = 0.05), while preoperative HbA1c changes were not associated with rebleeding. The results of this study suggest that a high preoperative HbA1c level just before vitrectomy, not a decrease in HbA1c levels, in addition to the duration of the operation may increase the risk of postoperative bleeding after vitrectomy in diabetic retinopathy patients.https://www.jstage.jst.go.jp/article/endocrj/71/10/71_EJ23-0301/_html/-char/endiabetic retinopathyhemoglobin a1c (hba1c)postoperative bleedingvitrectomy |
| spellingShingle | Saori Motoda Masanori Kanai Susumu Sakimoto Harutoshi Ozawa Chisaki Ishibashi Shingo Fujita Yoshiya Hosokawa Megu Y. Baden Yukari Fujita Takekazu Kimura Ayumi Tokunaga Takao Nammo Kenji Fukui Junji Kozawa Hirokazu Sakaguchi Kohji Nishida Iichiro Shimomura Preoperative hemoglobin A1c is associated with postoperative bleeding after vitrectomy for vitreous hemorrhage in patients with diabetic retinopathy Endocrine Journal diabetic retinopathy hemoglobin a1c (hba1c) postoperative bleeding vitrectomy |
| title | Preoperative hemoglobin A1c is associated with postoperative bleeding after vitrectomy for vitreous hemorrhage in patients with diabetic retinopathy |
| title_full | Preoperative hemoglobin A1c is associated with postoperative bleeding after vitrectomy for vitreous hemorrhage in patients with diabetic retinopathy |
| title_fullStr | Preoperative hemoglobin A1c is associated with postoperative bleeding after vitrectomy for vitreous hemorrhage in patients with diabetic retinopathy |
| title_full_unstemmed | Preoperative hemoglobin A1c is associated with postoperative bleeding after vitrectomy for vitreous hemorrhage in patients with diabetic retinopathy |
| title_short | Preoperative hemoglobin A1c is associated with postoperative bleeding after vitrectomy for vitreous hemorrhage in patients with diabetic retinopathy |
| title_sort | preoperative hemoglobin a1c is associated with postoperative bleeding after vitrectomy for vitreous hemorrhage in patients with diabetic retinopathy |
| topic | diabetic retinopathy hemoglobin a1c (hba1c) postoperative bleeding vitrectomy |
| url | https://www.jstage.jst.go.jp/article/endocrj/71/10/71_EJ23-0301/_html/-char/en |
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