Lutein Suppresses the Maturation and Function of Bone Marrow-Derived Dendritic Cells
Lutein, nonivamide, and baicalein, organic compounds found in a variety of plants, are known to exert anti-inflammatory effects in animal cells. Dendritic cells (DCs) are professional antigen-presenting cells (APCs) and link the innate and adaptive immune systems. DCs can be directed into fully mat...
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| Format: | Article |
| Language: | English |
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HH Publisher
2024-04-01
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| Series: | Progress in Microbes and Molecular Biology |
| Online Access: | https://journals.hh-publisher.com/index.php/pmmb/article/view/942 |
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| author | Seulah Choi Tae Sung Kim Hui Xuan Lim |
| author_facet | Seulah Choi Tae Sung Kim Hui Xuan Lim |
| author_sort | Seulah Choi |
| collection | DOAJ |
| description |
Lutein, nonivamide, and baicalein, organic compounds found in a variety of plants, are known to exert anti-inflammatory effects in animal cells. Dendritic cells (DCs) are professional antigen-presenting cells (APCs) and link the innate and adaptive immune systems. DCs can be directed into fully mature APCs by exposure to bacterial or viral components, resulting in inflammatory situations. The manipulation of DC maturation provides a strategy for the treatment of allergic and inflammatory diseases. In this study, we evaluated the effects of lutein, nonivamide, and baicalein on the maturation and activation of DCs. Compared to nonivamide and baicalein, lutein significantly and dose-dependently reduced the levels of maturation-associated cell surface markers, including CD40, co-stimulatory molecule CD86, and major histocompatibility complex class II (I-Ab) molecule in lipopolysaccharide (LPS)-stimulated DCs. Lutein also decreased IL-12p40 and IL-6 gene expression and secretion in LPS-stimulated DCs. Furthermore, lutein significantly enhanced the endocytic ability of LPS-stimulated DCs. These results demonstrated that lutein may exhibit immunosuppressive activity by inhibiting the phenotypic and functional maturation of DCs, and provide new evidence for the value of lutein in the search for novel therapeutic agents in the treatment of inflammatory diseases.
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| format | Article |
| id | doaj-art-f35770c6dfd441e8a2288c914b9c65ad |
| institution | Kabale University |
| issn | 2637-1049 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | HH Publisher |
| record_format | Article |
| series | Progress in Microbes and Molecular Biology |
| spelling | doaj-art-f35770c6dfd441e8a2288c914b9c65ad2025-02-04T08:39:39ZengHH PublisherProgress in Microbes and Molecular Biology2637-10492024-04-017110.36877/pmmb.a0000441Lutein Suppresses the Maturation and Function of Bone Marrow-Derived Dendritic CellsSeulah ChoiTae Sung KimHui Xuan Lim Lutein, nonivamide, and baicalein, organic compounds found in a variety of plants, are known to exert anti-inflammatory effects in animal cells. Dendritic cells (DCs) are professional antigen-presenting cells (APCs) and link the innate and adaptive immune systems. DCs can be directed into fully mature APCs by exposure to bacterial or viral components, resulting in inflammatory situations. The manipulation of DC maturation provides a strategy for the treatment of allergic and inflammatory diseases. In this study, we evaluated the effects of lutein, nonivamide, and baicalein on the maturation and activation of DCs. Compared to nonivamide and baicalein, lutein significantly and dose-dependently reduced the levels of maturation-associated cell surface markers, including CD40, co-stimulatory molecule CD86, and major histocompatibility complex class II (I-Ab) molecule in lipopolysaccharide (LPS)-stimulated DCs. Lutein also decreased IL-12p40 and IL-6 gene expression and secretion in LPS-stimulated DCs. Furthermore, lutein significantly enhanced the endocytic ability of LPS-stimulated DCs. These results demonstrated that lutein may exhibit immunosuppressive activity by inhibiting the phenotypic and functional maturation of DCs, and provide new evidence for the value of lutein in the search for novel therapeutic agents in the treatment of inflammatory diseases. https://journals.hh-publisher.com/index.php/pmmb/article/view/942 |
| spellingShingle | Seulah Choi Tae Sung Kim Hui Xuan Lim Lutein Suppresses the Maturation and Function of Bone Marrow-Derived Dendritic Cells Progress in Microbes and Molecular Biology |
| title | Lutein Suppresses the Maturation and Function of Bone Marrow-Derived Dendritic Cells |
| title_full | Lutein Suppresses the Maturation and Function of Bone Marrow-Derived Dendritic Cells |
| title_fullStr | Lutein Suppresses the Maturation and Function of Bone Marrow-Derived Dendritic Cells |
| title_full_unstemmed | Lutein Suppresses the Maturation and Function of Bone Marrow-Derived Dendritic Cells |
| title_short | Lutein Suppresses the Maturation and Function of Bone Marrow-Derived Dendritic Cells |
| title_sort | lutein suppresses the maturation and function of bone marrow derived dendritic cells |
| url | https://journals.hh-publisher.com/index.php/pmmb/article/view/942 |
| work_keys_str_mv | AT seulahchoi luteinsuppressesthematurationandfunctionofbonemarrowderiveddendriticcells AT taesungkim luteinsuppressesthematurationandfunctionofbonemarrowderiveddendriticcells AT huixuanlim luteinsuppressesthematurationandfunctionofbonemarrowderiveddendriticcells |