Antibodies to Cardiolipin in Patients with Primary Biliary Cirrhosis
Antibodies to cardiolipin have been recognized in up to 65% of patients with systemic lupus erythematosus. It has been claimed that they are significantly associated with intravascular thrombosis and with obstetrical complications. Thus far they have been found to be less prevalent in other diseases...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1989-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1989/806380 |
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| Summary: | Antibodies to cardiolipin have been recognized in up to 65% of
patients with systemic lupus erythematosus. It has been claimed that they are
significantly associated with intravascular thrombosis and with obstetrical complications.
Thus far they have been found to be less prevalent in other diseases.
Because of the high concentration of cardiolipin in mitochondrial membranes
and the presence of antimitochondrial antibodies in patients with primary biliary
cirrhosis, the authors investigated the prevalence of antibodies to cardiolipin in a
group of 31 patients with primary biliary cirrhosis. lt was found that the prevalence
and levels of anticardiolipin antibodies of lgG and lgA isotype are as high in
patients with primary biliary cirrhosis as in 35 consecutive patients with systemic
lupus erythematosus. None of the patients with primary biliary cirrhosis gave any
history of venous or arterial thrombosis. The rate of miscarriage was less than that
reported for the general population. The availability for study of a second group
of patients with high levels of anticardiolipin antibodies should make it possible
to determine whether the association of these antibodies with thrombosis and
fetal wastage in patients with systemic lupus erythematosus is a direct relation ship
or an epiphenomenon. |
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| ISSN: | 0835-7900 |