The role of endoplasmic reticulum aminopeptidase ERAP2 pathogenic mutation rs1363907 in amoxicillin clavulanate-induced liver injury: a special case report

The role of endoplasmic reticulum aminopeptidase ERAP2 pathogenic mutation rs1363907 in amoxicillin clavulanate-induced liver injury: a special case report

Idiosyncratic hepatotoxicity is a type of drug-induced liver injury (DILI) that is unpredictable and clinically severe, and amoxicillin clavulanate (AC) is the most implicated drug in DILI worldwide. The clinical manifestations of amoxicillin clavulanate-induced liver injury (AC-DILI) are fatigue an...

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Bibliographic Details
Main Authors: Yan Zhan, Jin-Mao Liao, Ling Ye, Long Zhang, Zheng Zhang, Ji-Ye Yin
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Pharmacology
Subjects:
AC-DILI
idiosyncratic hepatotoxicity
ERAP2
HLA polymorphism
autoimmune phenomena
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1564124/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1564124/full

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