Serine Proteases of Malaria Parasite Plasmodium falciparum: Potential as Antimalarial Drug Targets
Malaria is a major global parasitic disease and a cause of enormous mortality and morbidity. Widespread drug resistance against currently available antimalarials warrants the identification of novel drug targets and development of new drugs. Malarial proteases are a group of molecules that serve as...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Interdisciplinary Perspectives on Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2014/453186 |
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| author | Asrar Alam |
| author_facet | Asrar Alam |
| author_sort | Asrar Alam |
| collection | DOAJ |
| description | Malaria is a major global parasitic disease and a cause of enormous mortality and morbidity. Widespread drug resistance against currently available antimalarials warrants the identification of novel drug targets and development of new drugs. Malarial proteases are a group of molecules that serve as potential drug targets because of their essentiality for parasite life cycle stages and feasibility of designing specific inhibitors against them. Proteases belonging to various mechanistic classes are found in P. falciparum, of which serine proteases are of particular interest due to their involvement in parasite-specific processes of egress and invasion. In P. falciparum, a number of serine proteases belonging to chymotrypsin, subtilisin, and rhomboid clans are found. This review focuses on the potential of P. falciparum serine proteases as antimalarial drug targets. |
| format | Article |
| id | doaj-art-f34362cbcdc3442ea1a3b3efe726e4f2 |
| institution | Kabale University |
| issn | 1687-708X 1687-7098 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Interdisciplinary Perspectives on Infectious Diseases |
| spelling | doaj-art-f34362cbcdc3442ea1a3b3efe726e4f22025-02-03T00:59:32ZengWileyInterdisciplinary Perspectives on Infectious Diseases1687-708X1687-70982014-01-01201410.1155/2014/453186453186Serine Proteases of Malaria Parasite Plasmodium falciparum: Potential as Antimalarial Drug TargetsAsrar Alam0Department of Biological Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, Colaba, Mumbai 400005, IndiaMalaria is a major global parasitic disease and a cause of enormous mortality and morbidity. Widespread drug resistance against currently available antimalarials warrants the identification of novel drug targets and development of new drugs. Malarial proteases are a group of molecules that serve as potential drug targets because of their essentiality for parasite life cycle stages and feasibility of designing specific inhibitors against them. Proteases belonging to various mechanistic classes are found in P. falciparum, of which serine proteases are of particular interest due to their involvement in parasite-specific processes of egress and invasion. In P. falciparum, a number of serine proteases belonging to chymotrypsin, subtilisin, and rhomboid clans are found. This review focuses on the potential of P. falciparum serine proteases as antimalarial drug targets.http://dx.doi.org/10.1155/2014/453186 |
| spellingShingle | Asrar Alam Serine Proteases of Malaria Parasite Plasmodium falciparum: Potential as Antimalarial Drug Targets Interdisciplinary Perspectives on Infectious Diseases |
| title | Serine Proteases of Malaria Parasite Plasmodium falciparum: Potential as Antimalarial Drug Targets |
| title_full | Serine Proteases of Malaria Parasite Plasmodium falciparum: Potential as Antimalarial Drug Targets |
| title_fullStr | Serine Proteases of Malaria Parasite Plasmodium falciparum: Potential as Antimalarial Drug Targets |
| title_full_unstemmed | Serine Proteases of Malaria Parasite Plasmodium falciparum: Potential as Antimalarial Drug Targets |
| title_short | Serine Proteases of Malaria Parasite Plasmodium falciparum: Potential as Antimalarial Drug Targets |
| title_sort | serine proteases of malaria parasite plasmodium falciparum potential as antimalarial drug targets |
| url | http://dx.doi.org/10.1155/2014/453186 |
| work_keys_str_mv | AT asraralam serineproteasesofmalariaparasiteplasmodiumfalciparumpotentialasantimalarialdrugtargets |