GPX3 promotes cisplatin resistance in TNBC by manipulating ROS-TGFB1-ZEB2

GPX3 promotes cisplatin resistance in TNBC by manipulating ROS-TGFB1-ZEB2

Abstract Background Due to the lack of effective targeted therapies and the high likelihood of acquired resistance, triple-negative breast cancer (TNBC) remains one of the deadliest cancers affecting women globally. Investigating the mechanism underlying TNBC’s resistance to platinum-based chemother...

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Bibliographic Details
Main Authors: Qingyi Hu, Qianzhi Chen, Wen Yang, Anwen Ren, Jie Tan, Tao Huang
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Cell Communication and Signaling
Subjects:
Triple-negative breast cancer
Cisplatin
Chemoresistance
Online Access:https://doi.org/10.1186/s12964-025-02356-z
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